MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	Rank	Value Type	description	Interaction Map	Network Comparison Type	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 51 to 100 of 6456 in total

Value Type  : Measured
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	network_comparison	green
26	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Divided	1833.01	2.0534	892.67
	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Subtracted	23693.7	5430.7	18263
27	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	1834.33	2.04922	895.134
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Subtracted	23693.7	5430.7	18263
28	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Divided	1834.36	2.04912	895.194
	necdin. [swissprot;acc:q99608]	Subtracted	23693.7	5430.7	18263
29	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]	Divided	1834.52	2.04858	895.507
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Subtracted	23693.7	5430.7	18263
30	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]	Divided	1834.59	2.04837	895.633
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Subtracted	23693.7	5430.7	18263
31	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Divided	1834.63	2.04827	895.697
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Subtracted	23693.7	5430.7	18263
32	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided	1834.73	2.04793	895.893
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	23693.7	5430.7	18263
33	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]	Divided	1835.3	2.04611	896.972
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	23693.7	5430.7	18263
34	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Divided	1836.71	2.02382	907.546
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	23693.7	5430.7	18263
35	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]	Divided	1836.71	2.02378	907.564
	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Subtracted	23693.7	5430.7	18263
36	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Divided	1836.76	2.02344	907.741
	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Subtracted	23693.7	5430.7	18263
37	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Divided	1836.76	2.02339	907.763
	melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Subtracted	23693.7	5430.7	18263
38	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Divided	1836.76	2.02337	907.774
	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Subtracted	23693.7	5430.7	18263
39	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	Divided	1836.8	2.02312	907.903
	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Subtracted	23693.7	5430.7	18263
40	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Divided	1836.81	2.02297	907.978
	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Subtracted	23693.7	5430.7	18263
41	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Divided	1836.81	2.02297	907.978
	trophinin. [swissprot;acc:q12816]	Subtracted	23693.7	5430.7	18263
42	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]		21785.2	5359.1	16426.1
	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	Divided	1857.32	1.93827	958.237
43	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	Subtracted	21785.2	5359.1	16426.1
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	Divided	1881.02	1.83093	1027.36
44	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Subtracted	28136.5	5321.1	33457.6
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	Divided	1931.34	1.82652	1057.39
45	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]		1926.69	1.82448	1056.02
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Subtracted	27642.5	5202.1	22440.4
46	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]		24896.4	4464.7	20431.7
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	Divided	779.167	1.78438	1390.33
47	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]
	trs85 homolog. [swissprot;acc:q9y2l5]	Subtracted	24896.4	4464.7	20431.7
48	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	Divided	779.167	1.78438	1390.33
	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Subtracted	24806.9	4437	20369.9
49	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Divided	779.167	1.78438	1390.33
50	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	Subtracted	24473.9	4346.1	20127.8
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Divided	779.167	1.78438	1390.33

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.