Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 3113 to 3162 of 12912 in total
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
description
Value Type
red
green
network_comparison
779 deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321] Ranked 230.516 241.641 1.04826
ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972] Measured 5874.76 6533.36 1.11211
probable cation-transporting atpase 1 (ec 3.6.1.-). [swissprot;acc:q9nq11] Squared 32174 37487.2 1.16514
sprouty homolog 2 (spry-2). [swissprot;acc:o43597] Rooted 59.6869 63.6262 1.066
780 dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584] Ranked 232.762 243.933 1.04799
phosducin-like protein (phlp). [swissprot;acc:q13371] Rooted 62.2361 58.3858 1.06595
tata box binding protein (transcription initiation factor tfiid) (tata-box factor) (tata sequence-binding protein) (tbp). [swissprot;acc:p20226] Squared 32174 37487.2 1.16514
vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8] Measured 5874.76 6533.36 1.11211
781 replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694] Rooted 62.2361 58.3858 1.06595
ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183] Ranked 245.84 257.636 1.04798
secretory pathway component sec31b-1. [refseq;acc:nm_015490] Measured 5874.76 6533.36 1.11211
target of egr1, member 1 (nuclear); target of egr1, member 1. [refseq;acc:nm_025077] Squared 33900.6 39498 1.16511
782 importin alpha-4 subunit (karyopherin alpha-4 subunit) (qip1 protein). [swissprot;acc:o00629] 33893.6 39486.1 1.165
replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927] Rooted 62.2361 58.3858 1.06595
translin. [swissprot;acc:q15631] Ranked 224.385 235.131 1.04789
vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12] Measured 5874.74 6533.33 1.11211
783 hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934] Squared 27407.7 31927.7 1.16492
phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941] Rooted 62.2361 58.3858 1.06595
translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598] Ranked 224.385 235.131 1.04789
vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281] Measured 5874.78 6533.37 1.1121
784 dc11 protein. [refseq;acc:nm_020186] Squared 27407.7 31927.7 1.16492
dna repair protein rad52 homolog. [swissprot;acc:p43351] Rooted 62.2361 58.3858 1.06595
polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710] Ranked 224.385 235.131 1.04789
vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543] Measured 5874.77 6533.36 1.1121
785 amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905] Squared 27407.7 31927.7 1.16492
clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675] Rooted 62.2332 58.3925 1.06577
hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4] Measured 4997 5557.17 1.1121
neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863] Ranked 244.447 233.508 1.04685
786 40s ribosomal protein s9. [swissprot;acc:p46781] Rooted 52.0101 48.813 1.0655
5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-e). [swissprot;acc:p22557] Squared 27407.7 31927.7 1.16492
pyruvate carboxylase, mitochondrial precursor (ec 6.4.1.1) (pyruvic carboxylase) (pcb). [swissprot;acc:p11498] Measured 9304.83 10347.3 1.11204
rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555] Ranked 244.447 233.508 1.04685
787 down-regulated in metastasis. [refseq;acc:nm_014503]
uba/ubx 33.3 kda protein. [swissprot;acc:q04323] Rooted 64.5489 68.7769 1.0655
ubiquitin-activating enzyme e1c (uba3 homolog, yeast); ubiquitin-activating enzyme e1c (homologous to yeast uba3). [refseq;acc:nm_003968] Squared 27407.7 31927.7 1.16492
vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487] Measured 5890.49 6547.9 1.11161
788 ero1-like. [refseq;acc:nm_014584] Rooted 64.5489 68.7769 1.0655
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0] Ranked 138.705 132.538 1.04653
ubiquitin-activating enzyme e1 (a1s9 protein). [swissprot;acc:p22314] Squared 27407.7 31927.7 1.16492
vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488] Measured 5890.41 6547.81 1.11161
789 40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865] Ranked 224.244 234.511 1.04578
atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632] Measured 5890.59 6547.99 1.1116
calcium-binding mitochondrial carrier protein aralar1 (solute carrier family 25, member 12). [swissprot;acc:o75746] Squared 27407.7 31927.7 1.16492
midasin (midas-containing protein). [swissprot;acc:q9nu22] Rooted 54.2779 57.8311 1.06546
790 40s ribosomal protein s21. [swissprot;acc:p35265] Ranked 224.244 234.511 1.04578
melanoma antigen recognized by t cells 2. [refseq;acc:nm_018194] Squared 27407.7 31927.7 1.16492
parafibromin. [refseq;acc:nm_024529] Rooted 53.2852 56.7723 1.06544
vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050] Measured 5890.88 6548.28 1.1116
791 5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor (ec 2.3.1.37) (delta-aminolevulinate synthase) (delta-ala synthetase) (alas-h). [swissprot;acc:p13196] Squared 27407.7 31927.7 1.16492
cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642] Rooted 62.5007 58.6648 1.06539

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/