MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Value Type	Network Comparison Type	Gene	description	Rank	Filtered	Interaction Map	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 268 to 317 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	green	network_comparison	red
aminoacylase-1 (ec 3.5.1.14) (n-acyl-l-amino-acid amidohydrolase) (acy-1). [swissprot;acc:q03154]	1420	208.229	1.02084	203.979
aminoadipate-semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase; lysine-2-oxoglutarate reductase; aminoadipic semialdehyde synthase. [refseq;acc:nm_005763]	2064	205.939	1.00833	207.655
aminomethyltransferase, mitochondrial precursor (ec 2.1.2.10) (glycine cleavage system t protein) (gcvt). [swissprot;acc:p48728]	2544	212.262	1.00192	212.67
ammecr1 protein. [refseq;acc:nm_015365]	1577	218.982	1.01645	222.585
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	105	1.26667	133
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	139	225.68	1.20415	271.752
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	2490	195.08	1.00284	194.527
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	0.00001	1	0.00001
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636	195.384	1.00128	195.635
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	2663	204.549	1.00107	204.768
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	189.959	1.00096	190.142
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	240	254.15	1.11785	227.357
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586	213.75	1.00154	213.422
angiomotin. [refseq;acc:nm_133265]	2585
anillin, actin binding protein (scraps homolog, drosophila); anillin (drosophila scraps homolog), actin binding protein. [refseq;acc:nm_018685]	143	49	1.20408	59
ankyrin 2 (brain ankyrin) (ankyrin b) (ankyrin, nonerythroid). [swissprot;acc:q01484]	2519	216.341	1.00234	215.835
ankyrin 3 (ank-3) (ankyrin g). [swissprot;acc:q12955]	2518
ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	805	221.785	1.04425	212.386
annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	1088	213.378	1.0295	219.673
annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	1094	213.385	1.02938	219.655
antithrombin-iii precursor (atiii) (pro0309). [swissprot;acc:p01008]	2418	218.984	1.00359	218.2
apg3p; pc3-96 protein. [refseq;acc:nm_022488]	169	98.0548	1.18722	82.5916
apical-like protein (apxl protein). [swissprot;acc:q13796]	362	211.136	1.09641	231.492
apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	248	212.41	1.11719	237.302
apolipoprotein a-i binding protein; apoa-i binding protein. [refseq;acc:nm_144772]	1606	204.662	1.0159	207.916
apolipoprotein b-100 precursor (apo b-100) [contains: apolipoprotein b-48 (apo b-48)]. [swissprot;acc:p04114]	2151	219.366	1.00686	217.871
apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	1293	228.46	1.024	233.942
apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]	1014	235.422	1.03238	243.045
apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	1132	212.675	1.02731	218.484
apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	1111	212.123	1.02766	217.99
apoptosis-inducing factor (aif)-homologous mitochondrion-associated inducer of death; p53-responsive gene 3. [refseq;acc:nm_032797]	2421	209.454	1.00359	210.205
apurinic/apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; apex nuclease-like 2. [refseq;acc:nm_014481]	2531	215.787	1.00221	216.264
aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	2690	188.046	1.00077	188.191
aquaporin 5. [swissprot;acc:p55064]	2692	188.048		188.192
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	2691			188.193
aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	2694	188.081	1.00075	188.223
arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	1184	222.334	1.02586	216.729
arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	1110	222.782	1.02769	216.78
arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	947	205.191	1.03567	212.51
arginase 1 (ec 3.5.3.1) (liver-type arginase). [swissprot;acc:p05089]	1885	206.615	1.01064	204.44
arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540]	1886	206.682	1.01061	204.512
arginine-glutamic acid dipeptide (re) repeats; atrophin 1-like; arginine glutamic acid dipeptide re repeats. [refseq;acc:nm_012102]	1379	213.875	1.02148	218.47
arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	1478	211.066	1.01922	215.122
argininosuccinate lyase (ec 4.3.2.1) (arginosuccinase) (asal). [swissprot;acc:p04424]	2108	217.93	1.00726	216.36
argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	1546	221.474	1.01701	217.769
arginyl-trna synthetase-like; arginine-trna ligase. [refseq;acc:nm_020320]	2235	199.711	1.0062	200.95
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	2798	0.00001	1	0.00001
armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]	1714	203.844	1.01327	206.549
arp2/3 complex 16 kda subunit (p16-arc) (actin-related protein 2/3 complex subunit 5). [swissprot;acc:o15511]	2602	225.192	1.00141	224.875
arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [swissprot;acc:o15145]	2632	225.195	1.00135	224.891

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.