Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison

Results: HTML CSV LaTeX

Showing element 251 to 300 of 6456 in total

Value Type	Measured
Interaction Map	High confidence
Filtered	1

Rank	description	Network Comparison Type	red	green	network_comparison	
126	cysteine endopeptidase aut-like isoform b. [source:refseq;acc:nm_178326]	Divided	24250	18164.9	1.33499	
126	rad50-interacting protein 1. [source:refseq;acc:nm_021930]	Subtracted	450.5	2394.5	1944	
127	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [source:swissprot;acc:q9byz6]	Subtracted	450.5	2394.5	1944	
127	transcription factor jun-d. [source:swissprot;acc:p17535]	Divided	5638.2	7523.39	1.33436	
128	luc7-like 2; cgi-74 protein; cgi-59 protein. [source:refseq;acc:nm_016019]	Divided	4355.61	5810.82	1.3341	
128	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [source:swissprot;acc:p17987]	Subtracted	11004.2	12944.2	1940	
129	luc7-like; sarcoplasmic reticulum protein luc7b1. [source:refseq;acc:nm_018032]	Divided	4358.13	5811.49	1.33348	
129	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [source:refseq;acc:nm_015316]	Subtracted	15274.9	13346.9	1928	
130	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [source:refseq;acc:nm_138457]	Divided	2234.68	2978.53	1.33287	
130	p66 alpha. [source:refseq;acc:nm_017660]	Subtracted	12839	10911.1	1927.9	
131	forkhead box protein p1 (hspc215). [source:swissprot;acc:q9h334]	Divided	2234.73	2978.57	1.33285	
131	transcription repressor p66 beta component of the mecp1 complex. [source:refseq;acc:nm_020699]	Subtracted	12839	10911.1	1927.9	
132	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [source:swissprot;acc:q9bzs1]	Divided	2236.61	2980.35	1.33253	
132	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [source:swissprot;acc:p17735]	Subtracted	12839	10911.1	1927.9	
133	cell division protein kinase 3 (ec 2.7.1.-). [source:swissprot;acc:q00526]	Subtracted	12798.9	10887.2	1911.7	
133	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [source:refseq;acc:nm_007278]	Divided	23421.5	17580.4	1.33225	
134	g2/mitotic-specific cyclin b2. [source:swissprot;acc:o95067]	Subtracted	12796.8	10886	1910.8	
134	gaba-a receptor-associated protein. [source:sptrembl;acc:q9by60]	Divided	21785.2	16426.1	1.32626	
135	apg3p; pc3-96 protein. [source:refseq;acc:nm_022488]	Divided	21785.2	16426.1	1.32626	
135	transcription factor jun-b. [source:swissprot;acc:p17275]	Subtracted	5579.18	7488.4	1909.22	
136	cell division protein kinase 2 (ec 2.7.1.-) (p33 protein kinase). [source:swissprot;acc:p24941]	Subtracted	12787.6	10880.5	1907.1	
136	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [source:swissprot;acc:q13952]	Divided	3620.77	4763.34	1.31556	
137	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [source:swissprot;acc:p23511]	Divided	3620.77	4763.34	1.31556	
137	g2/mitotic-specific cyclin b1. [source:swissprot;acc:p14635]	Subtracted	12786.6	10879.9	1906.7	
138	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [source:refseq;acc:nm_014592]	Divided	2755.15	2094.3	1.31555	
138	tumor suppressor p53-binding protein 2 (p53-binding protein 2) (53bp2) (bcl2-binding protein) (bbp). [source:swissprot;acc:q13625]	Subtracted	15182.5	13277.9	1904.6	
139	cell division control protein 2 homolog (ec 2.7.1.-) (p34 protein kinase) (cyclin-dependent kinase 1) (cdk1). [source:swissprot;acc:p06493]	Subtracted	12780.7	10876.4	1904.3	
139	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [source:refseq;acc:nm_147183]	Divided	2759.61	2099.49	1.31442	
140	homeobox protein hlx1 (homeobox protein hb24). [source:swissprot;acc:q14774]	Subtracted	2597.5	698.5	1899	
140	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [source:refseq;acc:nm_173193]	Divided	2760.28	2100.27	1.31425	
141	hbs1-like. [source:refseq;acc:nm_006620]	Subtracted	2597.5	698.5	1899	
141	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [source:swissprot;acc:p43330]	Divided	4405.4	5782.08	1.3125	
142	metalloprotease 1; metalloprotease 1 (pitrilysin family). [source:refseq;acc:nm_014889]	Divided	9276.47	7090.37	1.30832	
142	transcription factor jun-d. [source:swissprot;acc:p17535]	Subtracted	5638.2	7523.39	1885.19	
143	beta-1,4 mannosyltransferase. [source:refseq;acc:nm_019109]	Divided	9275.1	7089.65	1.30826	
143	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [source:swissprot;acc:p33240]	Subtracted	15427.2	13572.8	1854.4	
144	nucleolysin tia-1 (rna-binding protein tia-1) (p40-tia-1) [contains: p15-tia-1]. [source:swissprot;acc:p31483]	Subtracted	4133.47	5945.32	1811.85	
144	sad1/unc-84 protein-like 1. [source:swissprot;acc:o94901]	Divided	3349.9	4362.61	1.30231	
145	nucleolysin tiar (tia-1 related protein). [source:swissprot;acc:q01085]	Subtracted	4136.36	5943.56	1807.2	
145	ubiquitin activating enzyme e1-like protein. [source:refseq;acc:nm_006395]	Divided	16771.5	12889.1	1.30122	
146	associated molecule with the sh3 domain of stam (amsh) like protein. [source:refseq;acc:nm_020799]	Divided	11068	8508.5	1.30082	
146	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [source:refseq;acc:nm_007266]	Subtracted	2671	871	1800	
147	protein x 0004. [source:refseq;acc:nm_016301]	Subtracted	2671	871	1800	
147	putative breast adenocarcinoma marker (32kd). [source:refseq;acc:nm_014453]	Divided	11068	8508.5	1.30082	
148	associated molecule with the sh3 domain of stam. [source:refseq;acc:nm_006463]	Divided	11068	8508.5	1.30082	
148	symplekin. [source:swissprot;acc:q92797]	Subtracted	15213.4	13418.1	1795.3	
149	neuroendocrine differentiation factor; comparative gene identification transcript 149. [source:refseq;acc:nm_016079]	Divided	11068	8508.5	1.30082	
149	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [source:swissprot;acc:o75648]	Subtracted	11736.6	13531.9	1795.3	
150	protein hspc134 (protein cda04). [source:swissprot;acc:q9by43]	Divided	11068	8508.5	1.30082	
150	small nuclear ribonucleoprotein sm d1 (snrnp core protein d1) (sm-d1) (sm-d autoantigen). [source:swissprot;acc:p13641]	Subtracted	4172.91	5954.48	1781.57	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.

- http://analysis.yellowcouch.org/