Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].
Gene Rank Value Type Network Comparison Type green Interaction Map description red network_comparison Filtered
Results: HTML CSV LaTeX Showing element 1918 to 1967 of 3228 in total
Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1
Rank
green
description
red
network_comparison
1918 200.18 endothelial-derived gene 1. [refseq;acc:nm_025205] 202.211 1.01015
1919 185.349 histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590] 187.231
1920 185.413 histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081] 187.292 1.01013
1921 219.386 5-methyltetrahydrofolate--homocysteine methyltransferase (ec 2.1.1.13) (methionine synthase, vitamin-b12 dependent) (ms). [swissprot;acc:q99707] 221.607 1.01012
1922 218.452 centaurin gamma 2. [swissprot;acc:q9upq3] 220.659 1.0101
1923 general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]
1924 centaurin gamma 1. [swissprot;acc:q99490]
1925 centaurin gamma 3. [swissprot;acc:q96p47]
1926 198.91 rhesus blood group, b glycoprotein; rh type b glycoprotein. [refseq;acc:nm_020407] 196.925 1.01008
1927 198.914 rhesus blood group-associated glycoprotein (erythrocyte plasma membrane 50 kda glycoprotein) (rh50a). [swissprot;acc:q02094] 196.932 1.01006
1928 198.935 blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161] 196.964 1.01001
1929 217.574 enigma protein; lim domain protein. [refseq;acc:nm_005451] 219.753
1930 198.935 blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577] 196.964
1931 217.574 eukaryotic translation initiation factor 3 subunit 7 (eif-3 zeta) (eif3 p66) (eif3d). [swissprot;acc:o15371] 219.753
1932 198.936 blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577] 196.965
1933 217.82 ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480] 215.667 1.00998
1934 222.055 gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8] 224.264 1.00995
1935 216.279 abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910] 218.43
1936 196.347 creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540] 198.3
1937 216.279 quaking isoform 6. [sptrembl;acc:q9p0x9] 218.43
1938 196.341 creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532] 198.293 1.00994
1939 196.319 peptidyl prolyl isomerase h; cyclophilin h. [refseq;acc:nm_006347] 198.258 1.00988
1940 196.252 creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277] 198.19
1941 196.319 prp18 pre-mrna processing factor 18 homolog. [refseq;acc:nm_003675] 198.258
1942 j domain protein c21orf55. [swissprot;acc:q9nx36] 198.257 1.00987
1943 222.147 megf11 protein. [refseq;acc:nm_032445] 224.34
1944 222.148 megf10 protein. [refseq;acc:nm_032446] 224.341
1945 222.151 beta adducin (erythrocyte adducin beta subunit). [swissprot;acc:p35612] 224.343
1946 212.142 nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384] 214.234 1.00986
1947 127.083 protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 125.845 1.00984
1948 212.432 15 kda selenoprotein precursor. [swissprot;acc:o60613] 214.522
1949 216.663 rna-binding protein with multiple splicing (rbp-ms). [swissprot;acc:q93062] 218.794
1950 213.747 vacuolar protein sorting 18 (hvps18). [swissprot;acc:q9p253] 215.847 1.00982
1951 203.873 trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646] 205.876
1952 213.724 importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294] 211.647 1.00981
1953 127.146 type 1 protein phosphatase inhibitor. [refseq;acc:nm_025210] 125.912 1.0098
1954 213.703 voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448] 211.632 1.00979
1955 yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470] 211.633 1.00978
1956 voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]
1957 similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]
1958 aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]
1959 alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]
1960 golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]
1961 alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]
1962 213.702 methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252] 211.632
1963 213.703 10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984] 211.633
1964 rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]
1965 222.258 alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611] 224.432
1966 213.703 oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8] 211.633
1967 213.702 choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329] 211.632

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/