MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	Rank	description	Network Comparison Type	Value Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1827 to 1876 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	green	red	network_comparison
914	guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388]	Subtracted	229.677	237.558	7.881
	pdz/coiled-coil domain binding partner for the rho-family gtpase tc10; fused in glioblastoma; golgi associated pdz and coiled-coil motif containing protein; cftr-associated ligand. [refseq;acc:nm_020399]	Divided	218.878	210.863	1.03801
915	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]		140.692	146.036	1.03798
	zuotin related factor-1 (m-phase phosphoprotein 11). [swissprot;acc:q99543]	Subtracted	229.677	237.558	7.881
916	histone h4. [swissprot;acc:p02304]		219.902	227.765	7.863
	hydroxyacid oxidase 2 (ec 1.1.3.15) (haox2) ((s)-2-hydroxy-acid oxidase, peroxisomal) (long chain alpha-hydroxy acid oxidase) (long- chain l-2-hydroxy acid oxidase). [swissprot;acc:q9nyq3]	Divided	241.288	232.512	1.03774
917	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Subtracted	78.8995	86.7483	7.8488
	parafibromin. [refseq;acc:nm_024529]	Divided	230.991	239.704	1.03772
918	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	Subtracted	210.139	217.942	7.803
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Divided	205.292	212.952	1.03731
919	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Subtracted	210.139	217.942	7.803
	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Divided	228.698	237.218	1.03725
920	breast cancer type 1 susceptibility protein. [swissprot;acc:p38398]	Subtracted	224.27	216.501	7.769
	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	Divided	245.547	236.741	1.0372
921	rio kinase 1 isoform 1; ad034 protein. [refseq;acc:nm_031480]
	wd-repeat protein bing4. [swissprot;acc:o15213]	Subtracted	235.475	243.227	7.752
922	map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	Divided	245.547	236.741	1.0372
	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Subtracted	207.942	215.665	7.723
923	hypoxanthine-guanine phosphoribosyltransferase (ec 2.4.2.8) (hgprt) (hgprtase). [swissprot;acc:p00492]		185.412	193.114	7.702
	map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	Divided	245.547	236.741	1.0372
924	meiotic recombination protein spo11. [swissprot;acc:q9y5k1]
	sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	Subtracted	231.059	238.725	7.666
925	pef protein with a long n-terminal hydrophobic domain (peflin). [refseq;acc:nm_012392]	Divided	207.942	215.665	1.03714
	protein bap28. [swissprot;acc:q9h583]	Subtracted	236.647	244.312	7.665
926	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	Divided	210.139	217.942	1.03713
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Subtracted	205.292	212.952	7.66
927	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	Divided	210.139	217.942	1.03713
	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Subtracted	212.618	220.246	7.628
928	peptide chain release factor 1, mitochondrial precursor (mrf-1). [swissprot;acc:o75570]	Divided	218.017	225.976	1.03651
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Subtracted	212.618	220.246	7.628
929	apoptosis antagonizing transcription factor. [refseq;acc:nm_012138]		235.422	243.045	7.623
	mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	Divided	218.015	225.955	1.03642
930	programmed cell death protein 5 (tfar19 protein) (tf-1 cell apoptosis related gene-19 protein). [swissprot;acc:o14737]	Subtracted	225.782	233.402	7.62
	pyruvate kinase, m1 isozyme (ec 2.7.1.40) (pyruvate kinase muscle isozyme) (cytosolic thyroid hormone-binding protein) (cthbp) (thbp1). [swissprot;acc:p14618]	Divided	239.778	231.357	1.0364
931	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]		164.917	159.13	1.03637
	prefoldin subunit 5 (c-myc binding protein mm-1) (myc modulator 1). [swissprot;acc:q99471]	Subtracted	221.421	228.953	7.532
932	mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	Divided	218.013	225.939	1.03636
	prefoldin subunit 6 (protein ke2). [swissprot;acc:o15212]	Subtracted	221.421	228.953	7.532
933	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	Divided	164.951	159.165	1.03635
	probable ribosome biogenesis protein nep1 (c2f protein). [swissprot;acc:q92979]	Subtracted	235.518	242.978	7.46
934	nucleolar rna-associated protein alpha isoform. [refseq;acc:nm_022917]	Divided	233.544	242.024	1.03631
	target of myb protein 1. [swissprot;acc:o60784]	Subtracted	209.824	217.254	7.43
935	huntingtin-associated protein-interacting protein (duo protein). [swissprot;acc:o60229]		209.826	217.253	7.427
	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	Divided	224.372	232.473	1.03611
936	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
	triple functional domain protein (ptprf interacting protein). [swissprot;acc:o75962]	Subtracted	209.827	217.253	7.426
937	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Divided	212.618	220.246	1.03588
	target of myb1-like 2; target of myb1 (chicken) homolog-like 2. [refseq;acc:nm_144678]	Subtracted	209.83	217.252	7.422
938	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]		205.087	212.442	7.355
	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Divided	212.618	220.246	1.03588

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.