MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Value Type	Network Comparison Type	Gene	description	Rank	Filtered	Interaction Map	green	network_comparison	red

Results: HTML CSV LaTeX

Showing element 1651 to 1700 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

description	Rank	green	network_comparison	red
microfibrillar-associated protein 1. [swissprot;acc:p55081]	2949	0.00001	1	0.00001
microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	927	210.139	1.03713	217.942
microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]	754	235.583	1.04968	224.434
microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	448	246.338	1.07822	228.468
microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	602	218.792	1.06069	206.274
microtubule-associated protein rp/eb family member 1 (apc-binding protein eb1). [swissprot;acc:q15691]	2719	216.632	1.00052	216.52
microtubule-associated protein rp/eb family member 3 (protein eb3). [swissprot;acc:q9upy8]	2720	216.633
microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	2717	216.634		216.521
microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	16	75.3954	1.32913	56.7252
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	15	75.3948	1.32914	56.7244
microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	2880	0.00001	1	0.00001
midasin (midas-containing protein). [swissprot;acc:q9nu22]	919	228.698	1.03725	237.218
mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	820	231.501	1.04413	221.716
mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	2607	215.799	1.0014	215.497
mitochondrial 28s ribosomal protein s30 (s30mt) (mrp-s30) (programmed cell death protein 9) (bm047). [swissprot;acc:q9np92]	3063	0.00001	1	0.00001
mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	996	212.547	1.03345	219.656
mitochondrial 28s ribosomal protein s6 (mrp-s6). [swissprot;acc:p82932]	2825	0.00001	1	0.00001
mitochondrial 60s ribosomal protein l27 (l27mt) (hspc250). [swissprot;acc:q9p0m9]	955	239.205	1.03479	231.163
mitochondrial 60s ribosomal protein l3 (l3mt). [swissprot;acc:p09001]	318	266.18	1.09987	242.011
mitochondrial deoxynucleotide carrier (mitochondrial uncoupling protein 1). [swissprot;acc:q9hc21]	3014	0.00001	1	0.00001
mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	698	209.118	1.05413	220.437
mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	1095	207.463	1.02935	213.552
mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	730	219.708	1.05187	208.874
mitochondrial import inner membrane translocase subunit tim22. [swissprot;acc:q9y584]	455	226.578	1.07779	210.225
mitochondrial import receptor subunit tom20 homolog (mitochondrial 20 kda outer membrane protein) (outer mitochondrial membrane receptor tom20). [swissprot;acc:q15388]	840	190.66	1.04259	198.781
mitochondrial precursor proteins import receptor (translocase of outer membrane tom70). [swissprot;acc:o94826]	2610	215.799	1.0014	215.497
mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	1300	212.576	1.02379	217.634
mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	1299	212.575	1.0238	217.635
mitochondrial ribosomal protein l17; lyst-interacting protein lip2. [refseq;acc:nm_022061]	361	266.248	1.09644	242.83
mitochondrial ribosomal protein l18. [refseq;acc:nm_014161]	2246	224.943	1.0061	223.58
mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	305	266.986	1.1017	242.339
mitochondrial ribosomal protein l22. [refseq;acc:nm_014180]	487	243.03	1.07387	226.313
mitochondrial ribosomal protein l24. [refseq;acc:nm_024540]	1985	217.193	1.00952	219.26
mitochondrial ribosomal protein l30 isoform a. [refseq;acc:nm_145212]	2477	216.801	1.00289	216.177
mitochondrial ribosomal protein l4 isoform a. [refseq;acc:nm_015956]	296	266.12	1.10294	241.282
mitochondrial ribosomal protein s7; 30s ribosomal protein s7 homolog. [refseq;acc:nm_015971]	3016	0.00001	1	0.00001
mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	663	216.576	1.0577	229.072
mitochondrial solute carrier protein. [refseq;acc:nm_016612]	2915	0.00001	1	0.00001
mitochondrial solute carrier protein. [refseq;acc:nm_145305]	27	44	1.31818	58
mitochondrial translational release factor 1-like. [refseq;acc:nm_019041]	932	218.013	1.03636	225.939
mitogen-activated protein kinase 1 (ec 2.7.1.37) (extracellular signal-regulated kinase 2) (erk-2) (mitogen-activated protein kinase 2) (map kinase 2) (mapk 2) (p42-mapk) (ert1). [swissprot;acc:p28482]	2168	214.486	1.00673	215.929
mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	1263	167.177	1.02425	171.231
mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	1274
mitogen-activated protein kinase 3 (ec 2.7.1.37) (extracellular signal-regulated kinase 1) (erk-1) (insulin-stimulated map2 kinase) (map kinase 1) (mapk 1) (p44-erk1) (ert2) (p44-mapk) (microtubule- associated protein-2 kinase). [swissprot;acc:p27361]	2159	214.474	1.00675	215.921
mitogen-activated protein kinase kinase 1 interacting protein 1 (mek binding partner 1) (mp1) (pro2783). [swissprot;acc:q9uha4]	3084	0.00001	1	0.00001
mitogen-activated protein kinase kinase kinase 5 (ec 2.7.1.-) (mapk/erk kinase kinase 5) (mek kinase 5) (mekk 5) (apoptosis signal- regulating kinase 1) (ask-1). [swissprot;acc:q99683]	2174	214.481	1.00673	215.925
mitogen-activated protein kinase kinase kinase 6 (ec 2.7.1.-). [swissprot;acc:o95382]	2163
mitogen-activated protein kinase kinase kinase 7 (ec 2.7.1.-) (transforming growth factor-beta-activated kinase 1) (tgf-beta- activated kinase 1). [swissprot;acc:o43318]	1489	209.264	1.01905	213.251
mitogen-activated protein kinase kinase kinase 7 interacting protein 1 (tak1-binding protein 1). [swissprot;acc:q15750]	2273	211.858	1.00546	213.015
mitogen-activated protein kinase kinase kinase 7 interacting protein 2 isoform 1; tak1-binding protein 2. [refseq;acc:nm_015093]	2342	230.294	1.00452	229.258

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.