Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 1144 to 1193 of 3228 in total 
Value Type	Ranked
Network Comparison Type	Divided
Interaction Map	High confidence
Filtered	1

Rank	description	red	green	network_comparison	
1144	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [source:swissprot;acc:q9ui12]	218.484	212.675	1.02731	
1145	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [source:swissprot;acc:q16864]	218.481	212.675	1.0273	
1146	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [source:swissprot;acc:p15313]	218.483	212.676	1.0273	
1147	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [source:swissprot;acc:o75381]	208.651	203.109	1.02729	
1148	ubiquitin. [source:swissprot;acc:p02248]	209.061	203.518	1.02724	
1149	bystin. [source:swissprot;acc:q13895]	239.505	233.185	1.0271	
1150	sorting nexin 1. [source:swissprot;acc:q13596]	209.868	215.522	1.02694	
1151	metaxin 1. [source:swissprot;acc:q13505]	199.552	204.925	1.02693	
1152	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [source:refseq;acc:nm_139204]	221.939	216.143	1.02682	
1153	epidermal growth factor receptor kinase substrate eps8. [source:swissprot;acc:q12929]	221.93	216.146	1.02676	
1154	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [source:swissprot;acc:q15181]	224.307	230.242	1.02646	
1155	inorganic pyrophosphatase 2 isoform 1. [source:refseq;acc:nm_176869]	224.307	230.242	1.02646	
1156	aryl-hydrocarbon interacting protein-like 1. [source:swissprot;acc:q9nzn9]	224.307	230.242	1.02646	
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [source:swissprot;acc:o00170]	224.307	230.242	1.02646	
1158	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [source:refseq;acc:nm_022772]	221.877	216.167	1.02641	
1159	proline synthetase co-transcribed bacterial homolog protein. [source:swissprot;acc:o94903]	170.28	165.898	1.02641	
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [source:swissprot;acc:q02218]	208.55	214.041	1.02633	
1161	kappa b-ras 1. [source:refseq;acc:nm_020345]	220.758	215.097	1.02632	
1162	i-kappa-b-interacting ras-like protein 2. [source:refseq;acc:nm_017595]	220.758	215.097	1.02632	
1163	snare associated protein snapin. [source:refseq;acc:nm_012437]	220.758	215.097	1.02632	
1164	transducin-like enhancer protein 4. [source:swissprot;acc:q04727]	219.438	213.818	1.02628	
1165	transducin-like enhancer protein 3 (esg3). [source:swissprot;acc:q04726]	219.401	213.785	1.02627	
1166	transducin-like enhancer protein 2 (esg2). [source:swissprot;acc:q04725]	219.374	213.759	1.02627	
1167	homeobox protein engrailed-2 (hu-en-2). [source:swissprot;acc:p19622]	219.399	213.784	1.02626	
1168	cpg binding protein (protein containing phd finger and cxxc domain 1). [source:swissprot;acc:q9p0u4]	219.399	213.784	1.02626	
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [source:refseq;acc:nm_013375]	219.399	213.784	1.02626	
1170	cytokine-like nuclear factor n-pac. [source:refseq;acc:nm_032569]	219.399	213.784	1.02626	
1171	hect type e3 ubiquitin ligase. [source:refseq;acc:nm_015052]	219.399	213.784	1.02626	
1172	transducin-like enhancer protein 1 (esg1). [source:swissprot;acc:q04724]	219.375	213.767	1.02623	
1173	candidate tumor suppressor in ovarian cancer 2. [source:refseq;acc:nm_080822]	229.243	235.246	1.02619	
1174	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [source:swissprot;acc:o14579]	187.964	192.849	1.02599	
1175	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [source:swissprot;acc:p27449]	218.186	212.672	1.02593	
1176	sarcoglycan zeta; zeta-sarcoglycan. [source:refseq;acc:nm_139167]	218.186	212.672	1.02593	
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [source:refseq;acc:nm_022735]	218.186	212.672	1.02593	
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [source:swissprot;acc:q92629]	218.186	212.672	1.02593	
1179	cellular modulator of immune recognition. [source:refseq;acc:nm_145021]	218.186	212.672	1.02593	
1180	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [source:swissprot;acc:q99437]	218.186	212.672	1.02593	
1181	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [source:swissprot;acc:q13326]	218.186	212.672	1.02593	
1182	neurocalcin delta. [source:swissprot;acc:p29554]	225.104	230.931	1.02589	
1183	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [source:swissprot;acc:p32076]	225.103	230.928	1.02588	
1184	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [source:swissprot;acc:q9y2x7]	216.729	222.334	1.02586	
1185	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [source:swissprot;acc:p37235]	225.094	230.913	1.02585	
1186	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [source:swissprot;acc:p56559]	218.402	212.904	1.02582	
1187	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [source:swissprot;acc:p12953]	218.402	212.904	1.02582	
1188	adp-ribosylation factor-like protein 4. [source:swissprot;acc:p40617]	218.402	212.904	1.02582	
1189	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [source:swissprot;acc:p19652]	209.649	204.406	1.02565	
1190	ubiquitin. [source:swissprot;acc:p02248]	209.6	204.372	1.02558	
1191	upstream binding protein 1 (lbp-1a). [source:refseq;acc:nm_014517]	220.742	215.237	1.02558	
1192	transcription factor cp2; transcription factor cp2, alpha globin. [source:refseq;acc:nm_005653]	220.742	215.237	1.02558	
1193	lbp-9. [source:refseq;acc:nm_014553]	220.742	215.237	1.02558	

Legend:
- Rank is the rank after comparing the two networks
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/