MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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green	Filtered	description	network_comparison	red	Value Type	Gene	Interaction Map	Rank	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2116 in total

green  : 0
Filtered  : 1
network_comparison  : 0
red  : 0
Interaction Map  : High confidence
Network Comparison Type  : Subtracted

description	Value Type	Rank
69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]	Measured	3227
	Ranked
	Squared
	Rooted
a-kinase anchor protein 5 (a-kinase anchor protein 79 kda) (akap 79) (camp-dependent protein kinase regulatory subunit ii high affinity binding protein) (h21). [swissprot;acc:p24588]	Measured	2788
	Ranked
	Squared
	Rooted
activin receptor type i precursor (ec 2.7.1.37) (actr-i) (serine/threonine-protein kinase receptor r1) (skr1) (activin receptor-like kinase 2) (alk-2) (tgf-b superfamily receptor type i) (tsr-i). [swissprot;acc:q04771]	Measured	3050
	Ranked
	Squared
	Rooted
adaptor protein with pleckstrin homology and src homology 2 domains. [refseq;acc:nm_020979]	Measured	2870
	Ranked
	Squared
	Rooted
aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]	Measured	3222
	Ranked
	Squared
	Rooted
aldehyde dehydrogenase 8 (ec 1.2.1.5). [swissprot;acc:p48448]	Measured	2992
	Ranked
	Squared
	Rooted
aldehyde oxidase (ec 1.2.3.1). [swissprot;acc:q06278]	Measured	2960
	Ranked
	Squared
	Rooted
alpha crystallin a chain. [swissprot;acc:p02489]	Measured	2875
	Ranked
	Squared
	Rooted
alpha crystallin b chain (alpha(b)-crystallin) (rosenthal fiber component). [swissprot;acc:p02511]	Measured	3082
	Ranked
	Squared
	Rooted
alveolar soft part sarcoma chromosome region, candidate 1; aspl protein; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17 gene; aspscr1/tfe3 fusion gene, included. [refseq;acc:nm_024083]	Measured	2829
	Ranked
	Squared
	Rooted
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	Measured	3191
	Ranked
	Squared
	Rooted
ariadne-2 protein homolog (ari-2) (triad1 protein) (ht005). [swissprot;acc:o95376]	Measured	2798
	Ranked
	Squared
	Rooted
atp synthase coupling factor 6, mitochondrial precursor (ec 3.6.3.14) (f6). [swissprot;acc:p18859]	Measured	2893
	Ranked

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.