Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Network Comparison Type Gene Value Type description Interaction Map red green Filtered network_comparison
Results: HTML CSV LaTeX Showing element 101 to 150 of 16578 in total
Value Type  : Measured
Filtered  : 1
Rank
Network Comparison Type
description
Interaction Map
red
green
network_comparison
26 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6] High confidence 1833.01 892.67 2.0534
sperm associated antigen 7. [refseq;acc:nm_004890] Low confidence 23318 19280.8 1.20939
Subtracted hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] High confidence 23693.7 18263 5430.7
septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599] Low confidence 13203.5 15033.4 1829.9
27 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150] High confidence 1834.33 895.134 2.04922
protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690] Low confidence 3840.85 4614.87 1.20152
Subtracted melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] High confidence 23693.7 18263 5430.7
microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8] Low confidence 13470.1 11654.4 1815.7
28 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798] High confidence 1834.36 895.194 2.04912
tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106] Low confidence 3098.94 3719.66 1.2003
Subtracted microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492] 13466.8 11652.4 1814.4
necdin. [swissprot;acc:q99608] High confidence 23693.7 18263 5430.7
29 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08] 1834.52 895.507 2.04858
tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616] Low confidence 3121.28 3739.84 1.19818
Subtracted melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] High confidence 23693.7 18263 5430.7
septin 10 isoform 1. [refseq;acc:nm_144710] Low confidence 13081.2 14872.6 1791.4
30 Divided bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090] 36474.3 43509.4 1.19288
guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670] High confidence 1834.59 895.633 2.04837
Subtracted melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 23693.7 18263 5430.7
phosphatidylinositol-glycan biosynthesis, class f protein (pig-f). [swissprot;acc:q07326] Low confidence 3278 5058.5 1780.5
31 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151] High confidence 1834.63 895.697 2.04827
vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274] Low confidence 36469.3 43503.3 1.19287
Subtracted melanoma antigen, family b, 6. [refseq;acc:nm_173523] High confidence 23693.7 18263 5430.7
n33 protein. [swissprot;acc:q13454] Low confidence 3278 5058.5 1780.5
32 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8] High confidence 1834.73 895.893 2.04793
nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333] Low confidence 36360.3 43368.8 1.19275
Subtracted implantation-associated protein. [refseq;acc:nm_032121] 3278 5058.5 1780.5
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] High confidence 23693.7 18263 5430.7
33 Divided guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152] 1835.3 896.972 2.04611
vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682] Low confidence 36360.3 43368.8 1.19275
Subtracted melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] High confidence 23693.7 18263 5430.7
septin 6. [swissprot;acc:q14141] Low confidence 13005.8 14773.7 1767.9
34 Divided guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992] High confidence 1836.71 907.546 2.02382
protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8] Low confidence 5339.5 6352.4 1.1897
Subtracted cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] 5492.04 7251 1758.96
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] High confidence 23693.7 18263 5430.7
35 Divided deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233] Low confidence 33111.4 39358.1 1.18866
guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148] High confidence 1836.71 907.564 2.02378
Subtracted melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] 23693.7 18263 5430.7
rhomboid-related protein 4 (ec 3.4.21.-) (ventrhoid transmembrane protein). [swissprot;acc:p58872] Low confidence 23239.9 21503.3 1736.6
36 Divided guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086] High confidence 1836.76 907.741 2.02344
proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] Low confidence 6462.09 7593.77 1.17513
Subtracted bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061] 23239.9 21503.3 1736.6
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] High confidence 23693.7 18263 5430.7
37 Divided guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488] 1836.76 907.763 2.02339
jun dimerization protein. [refseq;acc:nm_130469] Low confidence 6462.09 7593.77 1.17513
Subtracted melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] High confidence 23693.7 18263 5430.7
rhomboid-related protein 1 (ec 3.4.21.-) (rrp) (rhomboid-like protein 1). [swissprot;acc:o75783] Low confidence 23239.9 21503.3 1736.6
38 Divided guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087] High confidence 1836.76 907.774 2.02337
rab11-family interacting protein 4. [refseq;acc:nm_032932] Low confidence 7407.56 8696.7 1.17403

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/