MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Gene	Rank	Value Type	description	Network Comparison Type	red	Interaction Map	green	Filtered	network_comparison

Results: HTML CSV LaTeX

Showing element 101 to 150 of 1923 in total

Network Comparison Type  : Subtracted
red  : 0
Interaction Map  : High confidence
green  : 0
Filtered  : 1
network_comparison  : 0

Rank	Value Type	description
2773	Ranked	bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]
	Squared
	Rooted
2774	Measured	dc12 protein. [refseq;acc:nm_020187]
	Ranked
	Squared
	Rooted
2775	Measured	jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]
	Ranked
	Squared
	Rooted
2776	Measured	bcl-6 interacting corepressor isoform 1. [refseq;acc:nm_017745]
	Ranked
	Squared
	Rooted
2777	Measured	guanine nucleotide exchange factor mss4 (rab interacting factor). [swissprot;acc:p47224]
	Ranked
	Squared
	Rooted
2778	Measured	transcription factor mammalian mafa (pancreatic beta-cell specific transcriptional activator). [sptrembl;acc:q8nhw3]
	Ranked
	Squared
	Rooted
2779	Measured	caveolin-3 (m-caveolin). [swissprot;acc:p56539]
	Ranked
	Squared
	Rooted
2780	Measured	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]
	Ranked
	Squared
	Rooted
2781	Measured	exocyst complex component exo70. [swissprot;acc:q9upt5]
	Ranked
	Squared
	Rooted
2782	Measured	vacuolar atp synthase membrane sector associated protein m8-9 (v-atpase m8.9 subunit). [swissprot;acc:o75787]
	Ranked
	Squared
	Rooted
2783	Measured	mab-21-like protein 2; mab-21-like 2. [refseq;acc:nm_006439]
	Ranked
	Squared
	Rooted
2784	Measured	histone h2a.a (h2a/a) (h2a.2). [swissprot;acc:p28001]
	Ranked
	Squared
	Rooted
2785	Measured	nucleophosmin (npm) (nucleolar phosphoprotein b23) (numatrin) (nucleolar protein no38). [swissprot;acc:p06748]
	Ranked
	Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.