Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Rank Gene description Value Type Network Comparison Type Interaction Map Filtered red green network_comparison
Results: HTML CSV LaTeX Showing element 351 to 400 of 7460 in total
Value Type  : Ranked
Interaction Map  : High confidence
Rank
description
Network Comparison Type
Filtered
red
green
network_comparison
88 muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446] Subtracted 0 12787.8 10454.7 2333.1
regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795] 1 249.663 298.263 48.6
89 aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181] 0 12049 14370.7 2321.7
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] Divided 1 88.2482 110.265 1.24949
nuclear autoantigen sp-100 (speckled 100 kda) (nuclear dot-associated sp100 protein) (lysp100b). [swissprot;acc:p23497] 0 5677.58 4549.85 1.24786
putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37] Subtracted 1 249.663 298.263 48.6
90 60s ribosomal protein l18a. [swissprot;acc:q02543] 0 12738.7 10437.1 2301.6
high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13] Divided 5677.45 4550.87 1.24755
necdin. [swissprot;acc:q99608] 1 88.2482 110.265 1.24949
regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081] Subtracted 249.663 298.263 48.6
91 bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820] Divided 0 13841.2 11127.5 1.24387
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 88.2482 110.265 1.24949
suppressor of actin 1. [refseq;acc:nm_014016] Subtracted 0 19088.1 16804.6 2283.5
transcription factor lbx1. [swissprot;acc:p52954] 1 249.663 298.263 48.6
92 basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811] 0 11545 13771.5 2226.5
dok-like protein. [refseq;acc:nm_024872] Divided 17571 21783 1.23971
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 88.2482 110.265 1.24949
mosaic protein lgn. [swissprot;acc:p81274] Subtracted 249.663 298.263 48.6
93 melanoma antigen, family b, 6. [refseq;acc:nm_173523] Divided 88.2482 110.265 1.24949
pms1 protein homolog 2 (dna mismatch repair protein pms2). [swissprot;acc:p54278] 0 7739.47 9580.95 1.23793
pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322] Subtracted 10585.3 12769.1 2183.8
regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6] 1 249.663 298.263 48.6
94 guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252] 0 14222.5 12058.6 2163.9
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358] Divided 1 88.2482 110.265 1.24949
transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854] 0 12946.3 10519.7 1.23067
95 melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362] 1 88.2482 110.265 1.24949
pp3111 protein. [refseq;acc:nm_022156] 0 6185 7603 1.22926
rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736] Subtracted 1 249.663 298.263 48.6
zinc finger protein 232. [swissprot;acc:q9uny5] 0 11523.7 13686.9 2163.2
96 cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847] 1 201.949 153.671 48.278
imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549] Divided 0 8335.82 10228.3 1.22703
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361] 1 88.2482 110.265 1.24949
zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028] Subtracted 0 11523 13685.4 2162.4
97 amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410] 1 271.752 225.68 46.072
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732] Divided 88.2482 110.265 1.24949
microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378] 0 8335.82 10228.3 1.22703
zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58] Subtracted 11522.8 13684.9 2162.1
98 melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365] Divided 1 88.2482 110.265 1.24949
orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466] 0 7234.6 8858.94 1.22452
proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100] Subtracted 1 204.641 160.957 43.684
zinc finger imprinted 2. [swissprot;acc:q9nzv7] 0 11520.7 13680.4 2159.7
99 jun dimerization protein. [refseq;acc:nm_130469] 1 204.641 160.957 43.684
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355] Divided 88.2482 110.265 1.24949
muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446] 0 12787.8 10454.7 1.22316
repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273] Subtracted 7584.72 9706.12 2121.4
100 creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532] Divided 9183.49 11217.7 1.22151
dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880] Subtracted 12584.5 10470.6 2113.9
fos-related antigen 2. [swissprot;acc:p15408] 1 204.641 161.046 43.595
melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363] Divided 88.2482 110.265 1.24949

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/