Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Value Type Rank Gene description Interaction Map Filtered network_comparison green red Network Comparison Type
Results: HTML CSV LaTeX Showing element 601 to 650 of 38536 in total
Value Type  : Measured
Network Comparison Type  : Divided
Rank
description
Interaction Map
Filtered
network_comparison
green
red
151 cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2] Low confidence 1 1.08628 7751.87 7136.14
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] High confidence 1.29746 5939.91 4578.09
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 0 1.28932 1729.7 2230.13
williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] Low confidence 1.26808 323.685 410.457
152 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 1.26579 5898.71 4660.09
melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] High confidence 1 1.29736 18263 23693.7
nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323] Low confidence 1.08627 6016.13 5538.35
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] High confidence 0 1.28932 1729.7 2230.13
153 candidate tumor suppressor protein. [refseq;acc:nm_020381] Low confidence 1.26419 2821.67 2232
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] High confidence 1 1.29736 18263 23693.7
nipsnap1 protein. [swissprot;acc:q9bpw8] Low confidence 1.08611 6022.42 5544.97
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] High confidence 0 1.28932 1729.7 2230.13
154 glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 1 1.29736 18263 23693.7
monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021] Low confidence 1.08517 11452.8 10553.9
supervillin isoform 1; membrane-associated f-actin binding protein p205; archvillin. [refseq;acc:nm_003174] 0 1.26419 2821.67 2232
155 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 1.26273 5341.81 4230.36
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] High confidence 1 1.29736 18263 23693.7
solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593] Low confidence 1.08517 11452.6 10553.7
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] High confidence 0 1.28932 1729.7 2230.13
156 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 1 1.29736 18263 23693.7
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] Low confidence 0 1.25858 2118.44 1683.2
tho complex 3. [refseq;acc:nm_032361] 1 1.08467 8028.16 7401.51
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] High confidence 0 1.28932 1729.7 2230.13
157 brca1 associated protein. [refseq;acc:nm_006768] Low confidence 1.25567 1403.03 1117.36
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] High confidence 1 1.29736 18263 23693.7
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 0 1.28908 336.584 261.105
vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754] Low confidence 1 1.08462 8131.56 7497.17
158 guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] High confidence 0 1.28508 1649.37 1283.48
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 1 1.29736 18263 23693.7
mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749] Low confidence 1.08416 6976.28 6434.71
rho guanine nucleotide exchange factor (gef) 12; leukemia-associated rho guanine nucleotide exchange factor. [refseq;acc:nm_015313] 0 1.25474 944.615 752.839
159 brain protein 44. [swissprot;acc:o95563] 1 1.08349 11259.7 10392.1
dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2] 0 1.25423 612.604 488.43
lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] High confidence 1.27796 574.372 734.025
necdin. [swissprot;acc:q99608] 1 1.29736 18263 23693.7
160 huntingtin interacting protein c. [refseq;acc:nm_012272] 0 1.27566 1296.38 1653.74
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 1.29736 18263 23693.7
methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898] Low confidence 1.08304 11320.8 10452.8
testican-3 precursor. [swissprot;acc:q9bq16] 0 1.25401 805.916 642.672
161 glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] High confidence 1.27473 1152.06 903.767
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 1.29736 18263 23693.7
monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375] Low confidence 1.08298 11210.8 10351.8
protein c20orf142 precursor. [swissprot;acc:q8n6m3] 0 1.25 95 76
162 cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 1.24887 1107 1382.5
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] High confidence 1.26468 7252.02 5734.28
cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] Low confidence 1 1.08298 11472.3 12424.3
melanoma antigen, family b, 6. [refseq;acc:nm_173523] High confidence 1.29736 18263 23693.7
163 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985] Low confidence 1.08293 11206.7 10348.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/