MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Value Type	Filtered	green	Interaction Map	Gene	Rank	network_comparison	description	Network Comparison Type	red

Results: HTML CSV LaTeX

Showing element 501 to 550 of 77072 in total

Value Type  : Measured
Filtered  : 0

green	Interaction Map	Rank	network_comparison	description	Network Comparison Type	red
322.947	Low confidence	148	1.26947	williams beuren syndrome critical region 20a isoform 2; nol1/nop2/sun gene family member; williams-beuren syndrome critical region protein 20 copy a; williams beuren syndrome chromosome region 20. [refseq;acc:nm_018044]	Divided	409.972
		469	87.025		Subtracted
323.433		150	1.26852	williams beuren syndrome chromosome region 20c isoform 1. [refseq;acc:nm_032158]	Divided	410.28
		470	86.847		Subtracted
323.685		151	1.26808	williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645]	Divided	410.457
		471	86.772		Subtracted
327.517	High confidence	55	1.92644	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Divided	630.942
		103	303.425		Subtracted
330.189		54	1.93484	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Divided	638.862
		101	308.673		Subtracted
335		133	1.32937	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]	Divided	252
		314	83		Subtracted
336.584		157	1.28908	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	Divided	261.105
		319	75.479		Subtracted
	Low confidence	143	1.28908		Divided
		497	75.479		Subtracted
339.154	High confidence	207	1.19069	cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	Divided	403.827
		331	64.673		Subtracted
339.779	Low confidence	485	1.06422	phosphatidylinositol-4-phosphate 3-kinase c2 domain-containing beta polypeptide (ec 2.7.1.154) (phosphoinositide 3-kinase-c2-beta) (ptdins-3-kinase c2 beta) (pi3k-c2beta) (c2-pi3k). [swissprot;acc:o00750]	Divided	361.601
		733	21.822		Subtracted
346.751	High confidence	134	1.32862	mms19-like (met18 homolog, s. cerevisiae); homolog of yeast mms19; mms19 (met18 s. cerevisiae)-like. [refseq;acc:nm_022362]	Divided	260.986
		309	85.765		Subtracted
351.772		68	1.76802	protein regulator of cytokinesis 1; protein regulating cytokinesis 1. [refseq;acc:nm_003981]	Divided	198.964
		209	152.808		Subtracted
352.75		71	1.75762	ubiquitin protein ligase. [refseq;acc:nm_130466]	Divided	620
		119	267.25		Subtracted
354.349	Low confidence	318	1.16138	poly(rc)-binding protein 2 (alpha-cp2) (hnrnp-e2). [swissprot;acc:q15366]	Divided	305.111
		599	49.238		Subtracted
359.631	High confidence	120	1.37479	signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	Divided	494.417
		238	134.786		Subtracted
359.98		382	1.04852	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]	Divided	377.445
		433	17.465		Subtracted
362.023		383	1.04825	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]	Divided	379.489
		432	17.466		Subtracted
362.955	Low confidence	101	1.47569	60s ribosomal protein l37a. [swissprot;acc:p12751]	Divided	535.61
		301	172.655		Subtracted
363	High confidence	203	1.19408	microtubule-interacting protein that associates with traf3; interleukin 13 receptor alpha 1-binding protein-1. [refseq;acc:nm_015650]	Divided	304
		343	59		Subtracted
	Low confidence	296	1.19408		Divided
		555	59		Subtracted
368.317	High confidence	229	1.14829	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]	Divided	320.752
		370	47.565		Subtracted
369.011		227	1.14972	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	Divided	424.258
		349	55.247		Subtracted
372.961		145	1.29544	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Divided	287.903
		312	85.058		Subtracted
375.343	Low confidence	179	1.21433	alanine-glyoxylate aminotransferase 2-like 1. [refseq;acc:nm_031279]	Divided	455.789
		481	80.446		Subtracted
377.574	High confidence	146	1.29466	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Divided	291.639
		308	85.935		Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.