MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 744 to 793 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
744	SEPT6	septin 6. [swissprot;acc:q14141]	126.604	120.463	1.05098
745	SLC35B1	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	214.679	225.568	1.05072
746	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	250.465	238.38	1.0507
747	no value	trinucleotide repeat containing 15. [refseq;acc:nm_015575]
748	FBL	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	245.246	233.483	1.05038
749	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	221.968	211.326	1.05036
750	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]	222.138	211.503	1.05028
751	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	223.463	212.875	1.04974
752	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]
753	LBP	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	224.434	235.583	1.04968
754	SPCS2	microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]
755	UMPS	uridine 5'-monophosphate synthase (ump synthase) [includes: orotate phosphoribosyltransferase (ec 2.4.2.10) (oprtase); orotidine 5'- phosphate decarboxylase (ec 4.1.1.23) (ompdecase)]. [swissprot;acc:p11172]
756	CLPTM1	cleft lip and palate associated transmembrane protein 1. [refseq;acc:nm_001294]
757	BPI	bactericidal permeability-increasing protein precursor (bpi) (cap 57). [swissprot;acc:p17213]
758	PLTP	phospholipid transfer protein precursor (lipid transfer protein ii). [swissprot;acc:p55058]
759	OSTF1	osteoclast stimulating factor 1. [swissprot;acc:q92882]	231.809	243.289	1.04952
760	NAT10	upf0202 protein kiaa1709. [swissprot;acc:q9h0a0]	246.055	234.458	1.04946
761	CBLB	signal transduction protein cbl-b (sh3-binding protein cbl-b). [swissprot;acc:q13191]	213.325	203.303	1.0493
762	CBL	cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	213.256	203.237
763	N6AMT1	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	228.78	218.091	1.04901
764	PRPF3	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	222.082	211.707
765	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	229.045	218.343
766	TRIOBP	protein tara (trio-associated repeat on actin) (hrihfb2122). [swissprot;acc:q9h2d6]	213.804	224.226	1.04875
767	no value	rho interacting protein 3. [refseq;acc:nm_015134]	213.803	224.224	1.04874
768	DNAJB4	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]	210.946	221.225	1.04873
769	PERLD1	cab2. [refseq;acc:nm_033419]
770	DNAJB5	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]
771	DNAJB1	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]
772	ETF1	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]
773	VPS52	suppressor of actin mutations 2-like isoform b; dj1033b10.5. [refseq;acc:nm_022553]
774	MCFD2	multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	225.996	215.535	1.04854
775	no value	histone deacetylase 2 (hd2). [swissprot;acc:q92769]	226.003	215.541
776		dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	225.996	215.535
777	HDAC1	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	225.989	215.53	1.04853
778	SNX6	sorting nexin 6 (traf4-associated factor 2). [swissprot;acc:q9unh7]	209.191	219.332	1.04848
779	DCTD	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]	230.516	241.641	1.04826
780	POLR2F	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	232.762	243.933	1.04799
781	MRTO4	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	245.84	257.636	1.04798
782	no value	translin. [swissprot;acc:q15631]	224.385	235.131	1.04789
783	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]
784	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]
785	NET1	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	244.447	233.508	1.04685
786	ARHGEF3	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]
787	UTP20	down-regulated in metastasis. [refseq;acc:nm_014503]
788	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	138.705	132.538	1.04653
789	no value	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	224.244	234.511	1.04578
790	RPS21	40s ribosomal protein s21. [swissprot;acc:p35265]
791	SERPINB9	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]
792	no value	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
793	SERPINB10	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.