Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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green Filtered Value Type description Rank Gene Interaction Map network_comparison red Network Comparison Type
Results: HTML CSV LaTeX Showing element 1 to 50 of 38536 in total
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Network Comparison Type Divided
Value Type description Rank Interaction Map network_comparison red Measured brca1 associated protein. [source:refseq;acc:nm_006768] 502 High confidence 1 0.00001 Measured carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [source:refseq;acc:nm_021615] 22 Low confidence 3700000 37 Measured carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [source:refseq;acc:nm_004267] 23 Low confidence 3700000 37 Measured cobw-like protein. [source:refseq;acc:nm_018491] 839 Low confidence 1 0.00001 Measured dok-like protein. [source:refseq;acc:nm_024872] 31 High confidence 3500000 35 Measured ero1-like. [source:refseq;acc:nm_014584] 20 High confidence 8200000 82 Measured gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [source:refseq;acc:nm_080920] 838 Low confidence 1 0.00001 Measured gamma-glutamyltransferase. [source:sptrembl;acc:q14390] 841 Low confidence 1 0.00001 Measured gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [source:swissprot;acc:p19440] 842 Low confidence 1 0.00001 Measured gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [source:swissprot;acc:p36268] 837 Low confidence 1 0.00001 Measured gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [source:swissprot;acc:p36269] 843 Low confidence 1 0.00001 Measured h2a histone family, member j isoform 1. [source:refseq;acc:nm_018267] 501 High confidence 1 0.00001 Measured histone h2a.a (h2a/a) (h2a.2). [source:swissprot;acc:p28001] 495 High confidence 1 0.00001 Measured histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [source:swissprot;acc:p02261] 494 High confidence 1 0.00001 Measured histone h2a; h2a histone family, member r. [source:refseq;acc:nm_170745] 497 High confidence 1 0.00001 Measured homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [source:swissprot;acc:q93099] 6 Low confidence 1300000 13 Measured homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [source:swissprot;acc:q93099] 499 High confidence 1 0.00001 Measured mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [source:swissprot;acc:q9y6g3] 1 High confidence 36400000 364 Measured mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [source:swissprot;acc:q9y6g3] 1 Low confidence 36400000 364 Measured mitochondrial 28s ribosomal protein s6 (mrp-s6). [source:swissprot;acc:p82932] 496 High confidence 1 0.00001 Measured neurogenic locus notch homolog protein 1 precursor (notch 1) (hn1) (translocation-associated notch protein tan-1). [source:swissprot;acc:p46531] 44 Low confidence 28600000 286 Measured neurogenic locus notch homolog protein 2 precursor (notch 2) (hn2). [source:swissprot;acc:q04721] 45 Low confidence 28600000 286 Measured nuclear receptor co-repressor/hdac3 complex subunit tblr1 (tbl1- related protein 1). [source:swissprot;acc:q9bzk7] 95 High confidence 15400000 154 Measured rna helicase-related protein; rna helicase-like protein; sf3b125 dead-box protein. [source:refseq;acc:nm_007372] 65 High confidence 1800000 18 Measured rwd domain containing 1; ptd013 protein; cgi-24 protein. [source:refseq;acc:nm_015952] 500 High confidence 1 0.00001 Measured similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [source:refseq;acc:nm_032517] 22 High confidence 6000000 60 Measured tbc1 domain family, member 8 (with gram domain); vascular rab-gap/tbc-containing. [source:refseq;acc:nm_007063] 7 Low confidence 231962 2.31962 Measured transducin beta-like 1y protein (transducin-beta-like 1, y-linked). [source:swissprot;acc:q9bq87] 96 High confidence 15400000 154 Measured translin-associated protein x (translin-associated factor x). [source:swissprot;acc:q99598] 498 High confidence 1 0.00001 Measured translin-associated protein x (translin-associated factor x). [source:swissprot;acc:q99598] 840 Low confidence 1 0.00001 Ranked brca1 associated protein. [source:refseq;acc:nm_006768] 502 High confidence 1 0.00001 Ranked cobw-like protein. [source:refseq;acc:nm_018491] 839 Low confidence 1 0.00001 Ranked gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [source:refseq;acc:nm_080920] 838 Low confidence 1 0.00001 Ranked gamma-glutamyltransferase. [source:sptrembl;acc:q14390] 841 Low confidence 1 0.00001 Ranked gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [source:swissprot;acc:p19440] 842 Low confidence 1 0.00001 Ranked gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [source:swissprot;acc:p36268] 837 Low confidence 1 0.00001 Ranked gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [source:swissprot;acc:p36269] 843 Low confidence 1 0.00001 Ranked homogentisate 1,2-dioxygenase (ec 1.13.11.5) (homogentisicase) (homogentisate oxygenase) (homogentisic acid oxidase). [source:swissprot;acc:q93099] 501 High confidence 1 0.00001 Squared brca1 associated protein. [source:refseq;acc:nm_006768] 502 High confidence 1 0.00001 Squared carbohydrate (n-acetylglucosamine 6-o) sulfotransferase 6; macular dystrophy, corneal, 1; carbohydate sulfotransferase 6; corneal n-acetylglucosamine 6-sulfotransferase. [source:refseq;acc:nm_021615] 5 Low confidence 32402.4 0.324024 Squared carbohydrate (n-acetylglucosamine-6-o) sulfotransferase 2; carbohydrate (chondroitin 6/keratan) sulfotransferase 2. [source:refseq;acc:nm_004267] 6 Low confidence 32402.4 0.324024 Squared cobw-like protein. [source:refseq;acc:nm_018491] 839 Low confidence 1 0.00001 Squared dok-like protein. [source:refseq;acc:nm_024872] 13 High confidence 28994.1 0.289941 Squared ero1-like. [source:refseq;acc:nm_014584] 8 High confidence 159148 1.59148 Squared gamma-glutamyltransferase-like activity 4; gamma-glutamyltranspeptidase-like. [source:refseq;acc:nm_080920] 838 Low confidence 1 0.00001 Squared gamma-glutamyltransferase. [source:sptrembl;acc:q14390] 841 Low confidence 1 0.00001 Squared gamma-glutamyltranspeptidase 1 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 1) (cd224 antigen). [source:swissprot;acc:p19440] 842 Low confidence 1 0.00001 Squared gamma-glutamyltranspeptidase 2 (ec 2.3.2.2) (gamma-glutamyltransferase 2) (fragment). [source:swissprot;acc:p36268] 837 Low confidence 1 0.00001 Squared gamma-glutamyltranspeptidase 5 precursor (ec 2.3.2.2) (gamma- glutamyltransferase 5) (ggt-rel). [source:swissprot;acc:p36269] 843 Low confidence 1 0.00001 Squared h2a histone family, member j isoform 1. [source:refseq;acc:nm_018267] 501 High confidence 1 0.00001 Legend: - Rank is the rank after comparing the two networks - Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions. - Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them - Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions. - Filtered specifies whether we only included the high confidence microarry measurements or not.

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