MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Value Type	Interaction Map	Rank	Gene	description	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 451 to 500 of 1892 in total

Interaction Map  : High confidence
Network Comparison Type  : Subtracted
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Value Type	Rank	description
Measured	3206	protein c20orf43 (hspc164/hspc169) (ad-007) (cda05). [swissprot;acc:q9by42]
	3207	complement component c8 beta chain precursor. [swissprot;acc:p07358]
	3208	runt-related transcription factor 3 (core-binding factor, alpha 3 subunit) (cbf-alpha 3) (acute myeloid leukemia 2 protein) (oncogene aml-2) (polyomavirus enhancer binding protein 2 alpha c subunit) (pebp2-alpha c) (pea2-alpha c) (sl3-3 enhancer factor 1 alpha c subunit) (sl3/akv core-binding factor alpha c subunit). [swissprot;acc:q13761]
	3209	cdk-activating kinase assembly factor mat1 (ring finger protein mat1) (menage a trois) (cdk7/cyclin h assembly factor) (p36) (p35) (cyclin g1 interacting protein). [swissprot;acc:p51948]
	3210	trabid protein. [swissprot;acc:q9ugi0]
	3211	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]
	3212	rala binding protein 1; rala-binding protein. [refseq;acc:nm_006788]
	3213	malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]
	3214	bs4 protein (ny-ren-18 antigen). [swissprot;acc:q9y5a7]
	3215	membrane-bound transcription factor site 2 protease (ec 3.4.24.-) (site-2 protease) (sterol-regulatory element-binding proteins intramembrane protease). [swissprot;acc:o43462]
	3216	dna excision repair protein ercc-1. [swissprot;acc:p07992]
	3217	sex comb on midleg homolog 1. [refseq;acc:nm_012236]
	3218	williams-beuren syndrome chromosome region 14 protein (ws basic-helix- loop-helix leucine zipper protein) (ws-bhlh) (mlx interactor). [swissprot;acc:q9np71]
	3219	protein c6orf55 (dopamine responsive protein drg-1) (my012 protein) (hspc228). [swissprot;acc:q9np79]
	3220	transcription factor ap-2 beta (ap2-beta) (activating enhancer-binding protein 2 beta). [swissprot;acc:q92481]
	3221	platelet-activating factor acetylhydrolase ib alpha subunit (ec 3.1.1.47) (paf acetylhydrolase 45 kda subunit) (paf-ah 45 kda subunit) (paf-ah alpha) (pafah alpha) (lissencephaly-1 protein) (lis- 1). [swissprot;acc:p43034]
	3222	aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]
	3223	ras-related protein ral-a. [swissprot;acc:p11233]
	3224	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]
	3225	heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]
	3226	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]
	3227	69 kda islet cell autoantigen (ica69) (islet cell autoantigen 1) (islet cell autoantigen p69) (icap69). [swissprot;acc:q05084]
	3228	ezrin-binding partner pace-1 isoform 1. [refseq;acc:nm_020423]
Ranked	2756	3 beta-hydroxysteroid dehydrogenase (fragments). [sptrembl;acc:q9udk8]
	2757	nucleosome assembly protein 1-like 1 (nap-1 related protein). [swissprot;acc:p55209]
	2758	nucleosome assembly protein 1-like 2 (brain-specific protein, x- linked). [swissprot;acc:q9ulw6]
	2759	retinoic acid receptor rxr-alpha. [swissprot;acc:p19793]
	2760	t-cell acute lymphocytic leukemia-2 protein (tal-2 protein). [swissprot;acc:q16559]
	2761	guanine nucleotide-binding protein beta subunit-like protein 1 (g protein beta-subunit like protein 1) (wd40 repeat containing protein deleted in vcfs) (wdvcf protein) (fksg1 protein) (dgcrk3). [swissprot;acc:q9byb4]
	2762	developmentally regulated gtp-binding protein 1 (drg 1). [swissprot;acc:q9y295]
	2763	ring finger protein 3. [refseq;acc:nm_006315]
	2764	ras-related protein rab-11b (gtp-binding protein ypt3). [swissprot;acc:q15907]
	2765	histone h2a.e (h2a/e). [swissprot;acc:q99878]
	2766	ss18-like protein 1 (syt homolog-1). [swissprot;acc:o75177]
	2767	histone h2a.c/d/i/n/p (h2a.1) (h2a/c) (h2a/d) (h2a/i) (h2a/n) (h2a/p) (h2a.1b). [swissprot;acc:p02261]
	2768	histone h2a.x (h2a/x). [swissprot;acc:p16104]
	2769	histone h2a.q (h2a/q) (h2a-gl101) (fragment). [swissprot;acc:q16777]
	2770	nipsnap1 protein. [swissprot;acc:q9bpw8]
	2771	t-box transcription factor tbx1 (t-box protein 1) (testis-specific t-box protein). [swissprot;acc:o43435]
	2772	uridine diphosphate glucose pyrophosphatase. [refseq;acc:nm_177533]
	2773	bone morphogenetic protein 8 precursor (bmp-8) (osteogenic protein 2) (op-2). [swissprot;acc:p34820]
	2774	dc12 protein. [refseq;acc:nm_020187]
	2775	jerky protein homolog like (hhmjg). [swissprot;acc:q9y4a0]
	2776	bcl-6 interacting corepressor isoform 1. [refseq;acc:nm_017745]
	2777	guanine nucleotide exchange factor mss4 (rab interacting factor). [swissprot;acc:p47224]
	2778	transcription factor mammalian mafa (pancreatic beta-cell specific transcriptional activator). [sptrembl;acc:q8nhw3]
	2779	caveolin-3 (m-caveolin). [swissprot;acc:p56539]
	2780	importin alpha-2 subunit (karyopherin alpha-2 subunit) (srp1-alpha) (rag cohort protein 1). [swissprot;acc:p52292]
	2781	exocyst complex component exo70. [swissprot;acc:q9upt5]
	2782	vacuolar atp synthase membrane sector associated protein m8-9 (v-atpase m8.9 subunit). [swissprot;acc:o75787]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.