MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 330 to 379 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
83	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Measured	4932.27	7033.29	1.42597
	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, alpha isoform (pp2a, b subunit, b' alpha isoform) (pp2a, b subunit, b56 alpha isoform) (pp2a, b subunit, pr61 alpha isoform) (pp2a, b subunit, r5 alpha isoform). [swissprot;acc:q15172]	Squared	117718	70505.9	1.66962
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, beta isoform (pp2a, subunit a, pr65-beta isoform) (pp2a, subunit a, r1-beta isoform). [swissprot;acc:p30154]	Rooted	63.6507	48.7127	1.30666
84	b-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (p94) (v-raf murine sarcoma viral oncogene homolog b1). [swissprot;acc:p15056]	Squared	117515	70412.3	1.66896
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Ranked	88.2482	110.265	1.24949
	jun dimerization protein. [refseq;acc:nm_130469]	Measured	4932.27	7033.29	1.42597
	nuclear transcription factor y subunit gamma (nf-y protein chain c) (nuclear factor yc) (nf-yc) (ccaat-binding transcription factor subunit c) (cbf-c) (transactivator hsm-1/2). [swissprot;acc:q13952]	Rooted	46.7419	60.9337	1.30362
85	autophagy protein 12-like (apg12-like). [swissprot;acc:o94817]	Squared	67438.6	40697	1.65709
	ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	Rooted	46.7419	60.9337	1.30362
	fos-related antigen 2. [swissprot;acc:p15408]	Measured	4941.95	7037.11	1.42395
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Ranked	88.2482	110.265	1.24949
86	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Measured	4942.49	7037.32	1.42384
	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	Rooted	63.6205	48.8838	1.30146
	transforming protein p21a (k-ras 2a) (ki-ras) (c-k-ras). [swissprot;acc:p01116]	Squared	105500	64146.3	1.64468
87	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Rooted	42.2825	54.9687	1.30003
	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Measured	4944.3	7038.04	1.42347
	leucine-rich repeat protein shoc-2 (ras-binding protein sur-8). [swissprot;acc:q9uq13]	Squared	105482	64136.9	1.64464
	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	Ranked	88.2482	110.265	1.24949
88	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]
	potassium voltage-gated channel, shal-related subfamily, member 2; voltage-sensitive potassium channel; voltage-gated potassium channel kv4.2. [refseq;acc:nm_012281]	Measured	2411.93	1695.45	1.42259
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Rooted	37.3005	48.4141	1.29795
	ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211]	Squared	105482	64137.2	1.64463
89	cystathionine gamma-lyase (ec 4.4.1.1) (gamma-cystathionase). [swissprot;acc:p32929]	Measured	2414.22	1698.12	1.4217
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Ranked	88.2482	110.265	1.24949
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Rooted	37.3005	48.4141	1.29795
	transforming protein p21/h-ras-1 (c-h-ras). [swissprot;acc:p01112]	Squared	105473	64132.3	1.64462
90	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Rooted	37.3005	48.4141	1.29795
	necdin. [swissprot;acc:q99608]	Ranked	88.2482	110.265	1.24949
	potassium voltage-gated channel, shal-related subfamily, member 3 isoform 1; sha1-related potassium channel kv4.3; voltage-gated k+ channel; potassium ionic channel kv4.3; voltage-gated potassium channel kv4.3. [refseq;acc:nm_004980]	Measured	2414.77	1698.75	1.4215
	transforming protein n-ras. [swissprot;acc:p01111]	Squared	105469	64130.2	1.64461
91	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Rooted	37.3005	48.4141	1.29795
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Ranked	88.2482	110.265	1.24949
	potassium voltage-gated channel, shal-related subfamily, member 1; shal-type potassium channel; voltage-gated potassium channel kv4.1. [refseq;acc:nm_004979]	Measured	2416.53	1700.8	1.42082
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Squared	90432.9	56304.2	1.60615
92	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Measured	4117.67	5801.04	1.40882
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Ranked	88.2482	110.265	1.24949
	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	Squared	29570.7	18601.8	1.58967
	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Rooted	37.3005	48.4141	1.29795
93	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]	Squared	29567	18601.6	1.58949
	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	Rooted	37.3005	48.4141	1.29795
	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Measured	4245.52	5942.75	1.39977
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Ranked	88.2482	110.265	1.24949
94	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Rooted	47.6504	36.9304	1.29028
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	Measured	4247.86	5941.88	1.39879
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Ranked	88.2482	110.265	1.24949
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Squared	84857.8	53402.4	1.58903
95	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Ranked	88.2482	110.265	1.24949
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Squared	256169	162517	1.57626
	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Rooted	47.6504	36.9304	1.29028

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.