MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 244 to 293 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	green	network_comparison
244	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	4250.14	5211.25	1.22614
245	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	4251.65	5212.33	1.22595
246	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	4252.66	5213.05	1.22583
247	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	6416.68	7865.15	1.22574
248	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	6417.18	7859.6	1.22477
249	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]		7859.59
250	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]		7859.6
251	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]
252	crk-like protein. [swissprot;acc:p46109]
253	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]		7859.59
254	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]		7859.6
255	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]
256	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	6417.19	7859.51	1.22476
257	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	6417.31	7858.12	1.22452
258	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]	6417.33	7857.93	1.22449
259	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	6417.81	7852.52	1.22355
260	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	4244.95	5193.42	1.22343
261		4247.36	5192.61	1.22255
262	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	24896.4	20431.7	1.21852
263	trs85 homolog. [swissprot;acc:q9y2l5]
264	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	4987.58	4094.57	1.2181
265	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	24806.9	20369.9	1.21782
266	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]
267	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	14021.4	11523	1.21682
268	cleavage and polyadenylation specificity factor, 100 kda subunit (cpsf 100 kda subunit) (fragment). [swissprot;acc:q9p2i0]	24473.9	20127.8	1.21593
269	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	4590.18	5575.52	1.21466
270	fip1-like 1; rearranged in hypereosinophilia. [refseq;acc:nm_030917]	23640.2	19479.8	1.21358
271	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	2554.89	3093.78	1.21092
272	histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	3858.52	4669.27	1.21012
273	eukaryotic translation initiation factor 5 (eif-5). [swissprot;acc:p55010]	3199.4	3870.8	1.20985
274	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	3119.98	2579.49	1.20953
275	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]
276	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]
277	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]
278	transcription factor lbx1. [swissprot;acc:p52954]
279	mosaic protein lgn. [swissprot;acc:p81274]
280	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]
281	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]
282	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]
283	polymerase (dna directed) iota; rad30 (s. cerevisiae) homolog b; polymerase (dna-directed), iota. [refseq;acc:nm_007195]	5221.28	6314.35	1.20935
284	paxillin. [swissprot;acc:p49023]
285	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]	23326.5	19296.4	1.20885
286	exocyst complex component sec5. [swissprot;acc:q96kp1]	23316	19288.8	1.20878
287	poly(a) polymerase gamma (ec 2.7.7.19) (pap gamma) (polynucleotide adenylyltransferase gamma) (srp rna 3' adenylating enzyme). [swissprot;acc:q9bwt3]	23303.1	19279.5	1.2087
288	cleavage and polyadenylation specificity factor, 73 kda subunit (cpsf 73 kda subunit). [swissprot;acc:q9ukf6]	23422.4	19380.3	1.20857
289	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	4682.88	5646.19	1.20571
290	tuftelin-interacting protein 11 (hspc006). [swissprot;acc:q9ubb9]	4991.48	6014.08	1.20487
291	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	44490.5	36927.5	1.20481
292	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	4641.09	5588.75	1.20419
293	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.