Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Gene Value Type Rank description Interaction Map Filtered Network Comparison Type green red network_comparison
Results: HTML CSV LaTeX Showing element 601 to 650 of 38536 in total
Value Type  : Measured
Network Comparison Type  : Divided
Rank
description
Interaction Map
Filtered
green
red
network_comparison
151 cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2] Low confidence 1 7751.87 7136.14 1.08628
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] High confidence 5939.91 4578.09 1.29746
udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 0 1729.7 2230.13 1.28932
williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] Low confidence 323.685 410.457 1.26808
152 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 5898.71 4660.09 1.26579
melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] High confidence 1 18263 23693.7 1.29736
nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323] Low confidence 6016.13 5538.35 1.08627
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] High confidence 0 1729.7 2230.13 1.28932
153 candidate tumor suppressor protein. [refseq;acc:nm_020381] Low confidence 2821.67 2232 1.26419
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] High confidence 1 18263 23693.7 1.29736
nipsnap1 protein. [swissprot;acc:q9bpw8] Low confidence 6022.42 5544.97 1.08611
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] High confidence 0 1729.7 2230.13 1.28932
154 glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075]
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 1 18263 23693.7 1.29736
monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021] Low confidence 11452.8 10553.9 1.08517
supervillin isoform 1; membrane-associated f-actin binding protein p205; archvillin. [refseq;acc:nm_003174] 0 2821.67 2232 1.26419
155 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 5341.81 4230.36 1.26273
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] High confidence 1 18263 23693.7 1.29736
solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593] Low confidence 11452.6 10553.7 1.08517
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] High confidence 0 1729.7 2230.13 1.28932
156 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 1 18263 23693.7 1.29736
protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] Low confidence 0 2118.44 1683.2 1.25858
tho complex 3. [refseq;acc:nm_032361] 1 8028.16 7401.51 1.08467
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] High confidence 0 1729.7 2230.13 1.28932
157 brca1 associated protein. [refseq;acc:nm_006768] Low confidence 1403.03 1117.36 1.25567
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] High confidence 1 18263 23693.7 1.29736
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 0 336.584 261.105 1.28908
vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754] Low confidence 1 8131.56 7497.17 1.08462
158 guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] High confidence 0 1649.37 1283.48 1.28508
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 1 18263 23693.7 1.29736
mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749] Low confidence 6976.28 6434.71 1.08416
rho guanine nucleotide exchange factor (gef) 12; leukemia-associated rho guanine nucleotide exchange factor. [refseq;acc:nm_015313] 0 944.615 752.839 1.25474
159 brain protein 44. [swissprot;acc:o95563] 1 11259.7 10392.1 1.08349
dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2] 0 612.604 488.43 1.25423
lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] High confidence 574.372 734.025 1.27796
necdin. [swissprot;acc:q99608] 1 18263 23693.7 1.29736
160 huntingtin interacting protein c. [refseq;acc:nm_012272] 0 1296.38 1653.74 1.27566
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 1 18263 23693.7 1.29736
methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898] Low confidence 11320.8 10452.8 1.08304
testican-3 precursor. [swissprot;acc:q9bq16] 0 805.916 642.672 1.25401
161 glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] High confidence 1152.06 903.767 1.27473
melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 1 18263 23693.7 1.29736
monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375] Low confidence 11210.8 10351.8 1.08298
protein c20orf142 precursor. [swissprot;acc:q8n6m3] 0 95 76 1.25
162 cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 1107 1382.5 1.24887
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] High confidence 7252.02 5734.28 1.26468
cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] Low confidence 1 11472.3 12424.3 1.08298
melanoma antigen, family b, 6. [refseq;acc:nm_173523] High confidence 18263 23693.7 1.29736
163 melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]
monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985] Low confidence 11206.7 10348.5 1.08293

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/