MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Filtered	Gene	description	Value Type	Rank	Network Comparison Type	network_comparison	green	Interaction Map	red

Results: HTML CSV LaTeX

Showing element 1 to 50 of 77072 in total

Filtered  : 0

description	Value Type	Rank	Network Comparison Type	network_comparison	green	Interaction Map	red
1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Measured	37	Divided	2.79409	934.348	High confidence	334.401
		45	Subtracted	599.947
		131	Divided	1.31954	851.77	Low confidence	645.504
		273	Subtracted	206.266
	Ranked	172		1364.8	13895.8	High confidence	15260.6
		242	Divided	1.09822
		600	Subtracted	385	13590.3	Low confidence	13205.3
		629	Divided	1.02915
	Squared	37		10.2338	1034.13	High confidence	101.05
		131	Subtracted	933.08
		146	Divided	1.63527	1268.51	Low confidence	775.72
		319	Subtracted	492.79
	Rooted	53	Divided	1.5213	18.0183	High confidence	11.844
		69	Subtracted	6.1743
		537	Divided	1.04801	17.0804	Low confidence	16.298
		634	Subtracted	0.7824
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	Measured	627		43.53	4869.42		4825.89
		778	Divided	1.00902
	Ranked	627		1.02953	10050.9		10347.7
		641	Subtracted	296.8
	Squared	536		180.2	40451		40270.8
		815	Divided	1.00447
	Rooted	726	Subtracted	0.4144	39.5126		39.0982
		768	Divided	1.0106
25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Measured	19		11.6763	26.1599	High confidence	305.45
		115	Subtracted	279.29
		171	Divided	1.22585	181.734	Low confidence	222.779
		635	Subtracted	41.045
	Ranked	28		5557.5	18499.2	High confidence	12941.7
		47	Divided	1.42943
		220	Subtracted	1162.1	14695.2	Low confidence	13533.1
		384	Divided	1.08587
	Squared	26		128.828	0.344399	High confidence	44.3683
		336	Subtracted	44.0239
		697	Divided	1.03806	296.481	Low confidence	307.765
		749	Subtracted	11.284
	Rooted	26	Divided	3.62106	3.80565	High confidence	13.7805
		28	Subtracted	9.97485
		131	Divided	1.20585	9.42485	Low confidence	11.365
		376	Subtracted	1.94015
26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	Measured	380		40.82	2642.79	High confidence	2683.61
		451	Divided	1.01545
		762	Subtracted	16.2	1609.88	Low confidence	1593.68
		771	Divided	1.01017
	Ranked	378	Subtracted	422.4	10806	High confidence	11228.4
		379	Divided	1.03909
		822	Subtracted	21.4	11854.2	Low confidence	11832.8
		825	Divided	1.00181
	Squared	104	Subtracted	1264.81	7355.46	High confidence	8620.27
		316	Divided	1.17196

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.