MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	Network Comparison Type	Hugo	description	Value Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1751 to 1800 of 1892 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	Hugo	description	Value Type
3193	GDI2	rab gdp dissociation inhibitor beta (rab gdi beta) (gdi-2). [swissprot;acc:p50395]	Squared
			Rooted
3194	MSH4	muts protein homolog 4. [swissprot;acc:o15457]	Measured
			Ranked
			Squared
			Rooted
3195	ITGB3	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	Measured
			Ranked
			Squared
			Rooted
3196	HERPUD1	homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (methyl methanesulfonate (mmf)-inducible fragment protein 1). [swissprot;acc:q15011]	Measured
			Ranked
			Squared
			Rooted
3197	CLPTM1L	cisplatin resistance related protein crr9p. [refseq;acc:nm_030782]	Measured
			Ranked
			Squared
			Rooted
3198	DCUN1D1	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	Measured
			Ranked
			Squared
			Rooted
3199	C6	complement component c6 precursor. [swissprot;acc:p13671]	Measured
			Ranked
			Squared
			Rooted
3200	ZFYVE16	endosome-associated fyve-domain protein. [refseq;acc:nm_014733]	Measured
			Ranked
			Squared
			Rooted
3201	IFT88	recessive polycystic kidney disease protein tg737 homolog. [swissprot;acc:q13099]	Measured
			Ranked
			Squared
			Rooted
3202	RANBP3	ran binding protein 3 isoform ranbp3-d; ran-binding protein-3. [refseq;acc:nm_007322]	Measured
			Ranked
			Squared
			Rooted
3203	HMGB3	high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]	Measured
			Ranked
			Squared
			Rooted
3204	VRK2	vaccinia related kinase 2; vaccinia-related kinase-2. [refseq;acc:nm_006296]	Measured
			Ranked
			Squared
			Rooted
3205	RB1CC1	rb1-inducible coiled coil protein 1. [refseq;acc:nm_014781]	Measured
			Ranked
			Squared
			Rooted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.