Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Gene description Value Type Filtered Rank Network Comparison Type network_comparison Interaction Map green red
Results: HTML CSV LaTeX Showing element 451 to 500 of 9634 in total
Value Type  : Ranked
Network Comparison Type  : Divided
description
Filtered
Rank
network_comparison
Interaction Map
green
red
abhydrolase domain containing protein 2 (protein phps1-2). [swissprot;acc:p08910] 1 1935 1.00995 High confidence 216.279 218.43
2521 1.01814 Low confidence 197.494 201.076
abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759] 779 1.02662 197.229 202.48
1845 1.01106 High confidence 214.702 217.077
abl-philin 2. [refseq;acc:nm_032327] 0 389 1.08416 Low confidence 17688 16315
1 3025 1.01668 199.029 202.348
acetyl-coa acetyltransferase, mitochondrial precursor (ec 2.3.1.9) (acetoacetyl-coa thiolase) (t2). [swissprot;acc:p24752] 2259 1.01886 196.214 199.914
2306 1.00508 High confidence 192.544 191.571
acetyl-coa carboxylase 1 (ec 6.4.1.2) (acc-alpha) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:q13085] 2143 1.01914 Low confidence 193.896 197.608
2319 1.00492 High confidence 195.8 194.842
acetyl-coa carboxylase 2 (ec 6.4.1.2) (acc-beta) [includes: biotin carboxylase (ec 6.3.4.14)]. [swissprot;acc:o00763] 2144 1.01914 Low confidence 193.891 197.602
2315 1.00494 High confidence 195.787 194.825
acetyl-coenzyme a acetyltransferase 2; acetoacetyl coenzyme a thiolase. [refseq;acc:nm_005891] 4559 1.00798 Low confidence 200.117 201.714
acetyl-coenzyme a synthetase, cytoplasmic (ec 6.2.1.1) (acetate--coa ligase) (acyl-activating enzyme) (acetyl-coa synthetase) (acs) (acecs). [swissprot;acc:q9nr19] 2039 1.00861 High confidence 192.191 190.551
2376 1.01855 Low confidence 196.211 199.85
acetyl-coenzyme a transporter. [refseq;acc:nm_004733] 2713 1.01752 198.156 201.627
acid ceramidase precursor (ec 3.5.1.23) (acylsphingosine deacylase) (n-acylsphingosine amidohydrolase) (ac) (putative 32 kda heart protein) (php32). [swissprot;acc:q13510] 1421 1.02084 High confidence 211.391 207.076
2275 1.01882 Low confidence 199.972 203.735
acid sphingomyelinase-like phosphodiesterase 3a (ec 3.1.4.-) (asm-like phosphodiesterase 3a) (fragment). [swissprot;acc:q92484] 2956 1.01691 198.377 201.732
acid sphingomyelinase-like phosphodiesterase 3b precursor (ec 3.1.4.-) (asm-like phosphodiesterase 3b). [swissprot;acc:q92485] 2960
acidic 82 kda protein mrna. [refseq;acc:nm_014597] 4677 1.00595 201.278 202.475
acidic leucine-rich nuclear phosphoprotein 32 family member a (potent heat-stable protein phosphatase 2a inhibitor i1pp2a) (hla-dr associated protein i) (phapi) (acidic nuclear phosphoprotein pp32) (cerebellar leucine rich acidic nuclear protein). [swissprot;acc:p39687] 569 1.03088 200.275 206.46
acidic leucine-rich nuclear phosphoprotein 32 family member b (phapi2 protein) (silver-stainable protein ssp29) (acidic protein rich in leucines). [swissprot;acc:q92688] 572
acidic leucine-rich nuclear phosphoprotein 32 family member c (tumorigenic protein pp32r1). [swissprot;acc:o43423] 0 270 1.13916 15399 17542
1 567 1.03088 200.275 206.46
acidic leucine-rich nuclear phosphoprotein 32 family member d (tumorigenic protein pp32r2). [swissprot;acc:o95626] 0 271 1.13916 15399 17542
1 570 1.03088 200.275 206.46
aconitate hydratase, mitochondrial precursor (ec 4.2.1.3) (citrate hydro-lyase) (aconitase). [swissprot;acc:q99798] 1299 1.02237 195.959 200.342
acrc protein; putative nuclear protein. [refseq;acc:nm_052957] 0 21 1.68236 High confidence 10621.4 6313.38
322 1.10947 Low confidence 11238.6 10129.7
1 2101 1.00737 High confidence 213.27 211.71
2308 1.01869 Low confidence 197.572 201.265
actin binding lim protein 2. [refseq;acc:nm_032432] 660 1.0577 High confidence 216.576 229.072
820 1.02612 Low confidence 203.181 208.488
actin, alpha cardiac. [swissprot;acc:p04270] 3962 1.01209 198.479 200.879
actin, aortic smooth muscle (alpha-actin 2). [swissprot;acc:p03996] 0 668 1.02226 11418.9 11170.2
1 3964 1.01209 198.477 200.877
actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571] 0 382 1.03848 High confidence 10061.8 10449
829 1.00149 Low confidence 11085.2 11101.7
1 1529 1.01751 High confidence 213.031 216.762
3630 1.01418 Low confidence 197.828 200.633
actin, gamma-enteric smooth muscle (alpha-actin 3). [swissprot;acc:p12718] 3961 1.01209 198.477 200.877
actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313] 668 1.0577 High confidence 216.576 229.072
822 1.02612 Low confidence 203.181 208.488
actin-like protein 2 (actin-related protein 2). [swissprot;acc:o15142] 2626 1.00135 High confidence 225.195 224.891
3653 1.01403 Low confidence 198.345 201.127
actin-like protein 3 (actin-related protein 3) (actin-2). [swissprot;acc:p32391] 426 1.03512 198.528 205.501
2631 1.00135 High confidence 225.195 224.891
actin-related protein 2/3 complex subunit 1a (sop2-like protein). [swissprot;acc:q92747] 727 1.02743 Low confidence 196.189 201.571
2634 1.00135 High confidence 225.195 224.891

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
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