Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.


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Gene Rank Filtered description Value Type Network Comparison Type green Interaction Map red network_comparison
Results: HTML CSV LaTeX Showing element 601 to 650 of 9634 in total
Value Type  : Measured
Network Comparison Type  : Divided
Rank
Filtered
description
green
Interaction Map
red
network_comparison
151 0 udp-glucuronosyltransferase 2b17 precursor, microsomal (ec 2.4.1.17) (udpgt) (c19-steroid specific udp-glucuronosyltransferase). [swissprot;acc:o75795] 1729.7 High confidence 2230.13 1.28932
williams-beuren syndrome critical region protein 20 copy b. [refseq;acc:nm_145645] 323.685 Low confidence 410.457 1.26808
1 cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2] 7751.87 7136.14 1.08628
sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489] 5939.91 High confidence 4578.09 1.29746
152 0 cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 5898.71 Low confidence 4660.09 1.26579
udp-glucuronosyltransferase 2b11 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:o75310] 1729.7 High confidence 2230.13 1.28932
1 melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801] 18263 23693.7 1.29736
nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323] 6016.13 Low confidence 5538.35 1.08627
153 0 candidate tumor suppressor protein. [refseq;acc:nm_020381] 2821.67 2232 1.26419
udp-glucuronosyltransferase 2b4 precursor, microsomal (ec 2.4.1.17) (udpgt) (hyodeoxycholic acid) (hlug25) (udpgth-1). [swissprot;acc:p06133] 1729.7 High confidence 2230.13 1.28932
1 hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703] 18263 23693.7 1.29736
nipsnap1 protein. [swissprot;acc:q9bpw8] 6022.42 Low confidence 5544.97 1.08611
154 0 glutamyl aminopeptidase (ec 3.4.11.7) (eap) (aminopeptidase a) (apa) (differentiation antigen gp160). [swissprot;acc:q07075] 1729.7 High confidence 2230.13 1.28932
supervillin isoform 1; membrane-associated f-actin binding protein p205; archvillin. [refseq;acc:nm_003174] 2821.67 Low confidence 2232 1.26419
1 melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357] 18263 High confidence 23693.7 1.29736
monocarboxylate transporter 8 (mct 8) (x-linked pest-containing transporter) (mct 7). [swissprot;acc:p36021] 11452.8 Low confidence 10553.9 1.08517
155 0 cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326] 5341.81 4230.36 1.26273
udp-glucuronosyltransferase 2b10 precursor, microsomal (ec 2.4.1.17) (udpgt). [swissprot;acc:p36537] 1729.7 High confidence 2230.13 1.28932
1 melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364] 18263 23693.7 1.29736
solute carrier family 16 (monocarboxylic acid transporters), member 10; t-type amino acid transporter 1. [refseq;acc:nm_018593] 11452.6 Low confidence 10553.7 1.08517
156 0 protein phosphatase inhibitor 2 (ipp-2). [swissprot;acc:p41236] 2118.44 1683.2 1.25858
udp-glucuronosyltransferase 2b15 precursor, microsomal (ec 2.4.1.17) (udpgt) (udpgth-3) (hlug4). [swissprot;acc:p54855] 1729.7 High confidence 2230.13 1.28932
1 melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356] 18263 23693.7 1.29736
tho complex 3. [refseq;acc:nm_032361] 8028.16 Low confidence 7401.51 1.08467
157 0 brca1 associated protein. [refseq;acc:nm_006768] 1403.03 1117.36 1.25567
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476] 336.584 High confidence 261.105 1.28908
1 hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932] 18263 23693.7 1.29736
vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754] 8131.56 Low confidence 7497.17 1.08462
158 0 guanine nucleotide-binding protein beta subunit-like protein 12.3 (p205) (receptor of activated protein kinase c 1) (rack1) (receptor for activated c kinase). [swissprot;acc:p25388] 1649.37 High confidence 1283.48 1.28508
rho guanine nucleotide exchange factor (gef) 12; leukemia-associated rho guanine nucleotide exchange factor. [refseq;acc:nm_015313] 944.615 Low confidence 752.839 1.25474
1 melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360] 18263 High confidence 23693.7 1.29736
mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749] 6976.28 Low confidence 6434.71 1.08416
159 0 dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2] 612.604 488.43 1.25423
lipocalin-interacting membrane receptor. [refseq;acc:nm_018113] 574.372 High confidence 734.025 1.27796
1 brain protein 44. [swissprot;acc:o95563] 11259.7 Low confidence 10392.1 1.08349
necdin. [swissprot;acc:q99608] 18263 High confidence 23693.7 1.29736
160 0 huntingtin interacting protein c. [refseq;acc:nm_012272] 1296.38 1653.74 1.27566
testican-3 precursor. [swissprot;acc:q9bq16] 805.916 Low confidence 642.672 1.25401
1 melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3] 18263 High confidence 23693.7 1.29736
methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898] 11320.8 Low confidence 10452.8 1.08304
161 0 glycine cleavage system h protein, mitochondrial precursor. [swissprot;acc:p23434] 1152.06 High confidence 903.767 1.27473
protein c20orf142 precursor. [swissprot;acc:q8n6m3] 95 Low confidence 76 1.25
1 melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2] 18263 High confidence 23693.7 1.29736
monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375] 11210.8 Low confidence 10351.8 1.08298
162 0 cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247] 1107 1382.5 1.24887
cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936] 7252.02 High confidence 5734.28 1.26468
1 cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438] 11472.3 Low confidence 12424.3 1.08298
melanoma antigen, family b, 6. [refseq;acc:nm_173523] 18263 High confidence 23693.7 1.29736
163 0 myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1] 6193.07 7830.62 1.26442
voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02] 1388.74 Low confidence 1113.87 1.24677

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.
- http://analysis.yellowcouch.org/