MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Filtered	Value Type	green	Rank	network_comparison	Gene	Interaction Map	description	red	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 451 to 500 of 77072 in total

Filtered  : 0
Value Type  : Measured

green	Rank	network_comparison	Interaction Map	description	red	Network Comparison Type
206.5	434	1.02736	High confidence	testis-specific protein tpx-1 precursor (cysteine-rich secretory protein-2) (crisp-2). [swissprot;acc:p16562]	201	Divided
	459	5.5				Subtracted
210	117	1.35238	Low confidence	helicase/primase complex protein. [refseq;acc:nm_138336]	284	Divided
	504	74				Subtracted
219.891	392	1.04238	High confidence	60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	229.211	Divided
	452	9.32				Subtracted
221.565	469	1.00822		transcription factor btf3 homolog 3. [swissprot;acc:q13892]	219.759	Divided
	490	1.806				Subtracted
224.096	94	1.54338		myosin vi. [swissprot;acc:q9um54]	345.865	Divided
	95		Low confidence
	259	121.769	High confidence			Subtracted
	395		Low confidence
226.797	399	1.10398		similar to lysozyme c-1 (1,4-beta-n-acylmuramidase c, ec 3.2.1.17). [refseq;acc:nm_032517]	250.379	Divided
	723	23.582				Subtracted
226.81	410	1.03704	High confidence	glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]	218.71	Divided
	456	8.1				Subtracted
227.143	408	1.03704		glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]	219.031	Divided
	455	8.112				Subtracted
227.308	409	1.03704		glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]	219.19	Divided
	454	8.118				Subtracted
234.276	94	1.54599	Low confidence	poly (adp-ribose) glycohydrolase. [refseq;acc:nm_003631]	362.189	Divided
	379	127.913				Subtracted
241.74	120	1.3378		proactivator polypeptide precursor [contains: saposin a (protein a); saposin b (sphingolipid activator protein 1) (sap-1) (cerebroside sulfate activator) (csact) (dispersin) (sulfatide/gm1 activator); saposin c (co-beta-glucosidase) (a1 activator) (glucosylceramidase activator) (sphingolipid activator protein 2) (sap-2); saposin d (protein c) (component c)]. [swissprot;acc:p07602]	180.7	Divided
	547	61.04				Subtracted
249.857	487	1.00225	High confidence	ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]	250.419	Divided
	488			ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
	492	0.562		ras-related c3 botulinum toxin substrate 1 (p21-rac1) (ras-like protein tc25). [swissprot;acc:p15154]		Subtracted
	493			ras-related c3 botulinum toxin substrate 3 (p21-rac3). [swissprot;acc:o14658]
268.468	572	1.04582	Low confidence	transcription factor bteb4 (basic transcription element binding- protein 4) (bte-binding protein 4) (krueppel-like factor 16) (novel sp1-like zinc finger transcription factor 2) (transcription factor nslp2). [swissprot;acc:q9bxk1]	280.768	Divided
	781	12.3				Subtracted
277.003	168	1.23006		transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]	340.73	Divided
	542	63.727				Subtracted
279.24	59	1.85328	High confidence	f-actin capping protein alpha-2 subunit (capz alpha-2). [swissprot;acc:p47755]	150.673	Divided
	246	128.567				Subtracted
290.667	103	1.47298		transketolase-like 1 (ec 2.2.1.1) (transketolase 2) (tk 2) (transketolase related protein). [swissprot;acc:p51854]	197.333	Divided
	283	93.334				Subtracted
299.876	84	1.64861	Low confidence	sedlin. [swissprot;acc:o14582]	181.896	Divided
	402	117.98				Subtracted
305.886	70	1.82368		synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	167.73	Divided
	355	138.156				Subtracted
306.727	183	1.22281	High confidence	blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]	375.07	Divided
	184			blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
	326	68.343		blood group rh(d) polypeptide (rhesus d antigen) (rhxiii) (rh polypeptide 2) (rhpii). [swissprot;acc:q02161]		Subtracted
	327			blood group rh(ce) polypeptide (rhesus c/e antigens) (rh30a) (rhixb) (rh polypeptide 1) (rhpi). [swissprot;acc:p18577]
306.933	185	1.22281			375.322	Divided
	325	68.389				Subtracted
315.505	59	2.14473	Low confidence	nadph oxidase, ef hand calcium-binding domain 5. [refseq;acc:nm_024505]	147.107	Divided
	309	168.398				Subtracted
315.567	60	2.14463		nadph oxidase homolog 1 (nox-1) (noh-1) (nadh/nadph mitogenic oxidase subunit p65-mox) (mitogenic oxidase 1) (mox1). [swissprot;acc:q9y5s8]	147.143	Divided
	308	168.424				Subtracted

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.