MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1230 to 1279 of 3228 in total

Value Type  : Measured
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	red	green	network_comparison
1230	dystrobrevin binding protein 1; dysbindin. [refseq;acc:nm_032122]	5678.02	6161.65	1.08518
1231	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	5132.68	5569.54	1.08511
1232	nuclear factor, interleukin 3 regulated. [refseq;acc:nm_005384]	5869.24	6367.8	1.08494
1233	tyrosinase precursor (ec 1.14.18.1) (monophenol monooxygenase) (tumor rejection antigen ab) (sk29-ab) (lb24-ab). [swissprot;acc:p14679]	6004.54	6514.24	1.08489
1234	similar to ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_145245]	5807.83	6300.47	1.08482
1235	ecotropic viral integration site 5; neuroblastoma stage 4s gene. [refseq;acc:nm_005665]
1236	p10-binding protein. [refseq;acc:nm_024491]	5594.18	6067.49	1.08461
1237	tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	5873.56	6370.31	1.08457
1238	sphingolipid delta 4 desaturase; membrane fatty acid (lipid) desaturase; dihydroceramide desaturase. [refseq;acc:nm_003676]
1239	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	5654.53	6132.76
1240	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	5654.54	6132.69	1.08456
1241	26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	6436.19	6980.13	1.08451
1242	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	11143.5	10276.3	1.08439
1243	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]
1244	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	4835.55	5243.23	1.08431
1245	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]
1246	p53-related protein kinase (ec 2.7.1.-) (nori-2). [swissprot;acc:q96s44]	5346.11	5796.72	1.08429
1247	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	6278.76	6807.51	1.08421
1248	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	6275.86	6803.95	1.08415
1249	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	4413.55	4784.6	1.08407
1250	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	10733.4	9902.6	1.0839
1251	regulator of chromosome condensation (cell cycle regulatory protein). [swissprot;acc:p18754]	8618.32	9340.98	1.08385
1252	zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]
1253	transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]
1254	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	10725.6	9896.32	1.0838
1255	serine/threonine protein phosphatase 4 (ec 3.1.3.16) (pp4) (protein phosphatase x) (pp-x). [swissprot;acc:p33172]	5438.66	5893.87	1.0837
1256	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	10719	9891.08
1257	immunoglobulin-binding protein 1 (cd79a-binding protein 1) (b cell signal transduction molecule alpha 4) (alpha 4 protein). [swissprot;acc:p78318]	5438.66	5893.87
1258	glutamate carboxypeptidase-like protein 2 precursor. [swissprot;acc:q96kn2]	6251.32	6774.12	1.08363
1259	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	5685.38	6157.7	1.08308
1260	rad54-like protein; rad54 homolog. [refseq;acc:nm_003579]	5754.84	6232.83	1.08306
1261	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	5685.34	6157.53	1.08305
1262	serine/threonine protein kinase 23 (ec 2.7.1.37) (muscle-specific serine kinase 1) (mssk-1). [swissprot;acc:q9upe1]	5894.47	6383.73	1.083
1263	gtp binding protein 2. [refseq;acc:nm_019096]
1264	cyclic-amp-dependent transcription factor atf-6 beta (activating transcription factor 6 beta) (atf6-beta) (camp responsive element binding protein-like 1) (camp response element binding protein-related protein) (creb-rp) (g13 protein). [swissprot;acc:q99941]
1265	dna segment on chromosome 6(unique) 2654 expressed sequence; dna segment on chromosome x (unique) 2654 expressed sequence. [refseq;acc:nm_012135]
1266	sfrs protein kinase 2 isoform b. [refseq;acc:nm_182691]
1267	cyclic-amp-dependent transcription factor atf-6 alpha (activating transcription factor 6 alpha) (atf6-alpha). [swissprot;acc:p18850]
1268	sfrs protein kinase 1; sr protein kinase 1. [refseq;acc:nm_003137]
1269	xap-5 protein (hxc-26 protein). [swissprot;acc:q14320]
1270	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	5685.08	6156.48	1.08292
1271	mitotic checkpoint serine/threonine-protein kinase bub1 beta (ec 2.7.1.-) (hbubr1) (mad3/bub1-related protein kinase) (mitotic checkpoint kinase mad3l). [swissprot;acc:o60566]	5528.65	5985.58	1.08265
1272	pyridoxine 5'-phosphate oxidase. [refseq;acc:nm_018129]
1273	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	5885	6371.14	1.08261
1274	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
1275	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]
1276	peroxisomal membrane protein 2 (22 kda peroxisomal membrane protein). [swissprot;acc:q9nr77]	6437.99	6969.67	1.08258
1277	heat shock-related 70 kda protein 2 (heat shock 70 kda protein 2). [swissprot;acc:p54652]
1278	heat shock 70 kda protein 1 (hsp70.1) (hsp70-1/hsp70-2). [swissprot;acc:p08107]
1279	heat shock cognate 71 kda protein. [swissprot;acc:p11142]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.