MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis

Table 3: Type II network, divided ranks. This table presents the output of the simulation of a type-II network in which we relied on the high confidence interactions and micro-array results. The output of the micro-array was then ranked and these ranks used as input into the network simulation. After performing two such simulations (one for the MK5 off and one for the MK5 on microarray output), we divided the ranks and sorted the results accordingly. The output of this technique is a collection of proteins that cluster naturally together.

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	green	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1132 to 1181 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	green	red	network_comparison
1132	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	212.675	218.484	1.02731
1133	sec13-related protein. [swissprot;acc:p55735]
1134	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]
1135	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]
1136	yeast sec31p homolog. [refseq;acc:nm_014933]
1137	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]
1138	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]
1139	ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]
1140	dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804]
1141	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]
1142	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]
1143	secretory pathway component sec31b-1. [refseq;acc:nm_015490]
1144	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]
1145	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]		218.481	1.0273
1146	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	212.676	218.483
1147	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381]	203.109	208.651	1.02729
1148	ubiquitin. [swissprot;acc:p02248]	203.518	209.061	1.02724
1149	bystin. [swissprot;acc:q13895]	233.185	239.505	1.0271
1150	sorting nexin 1. [swissprot;acc:q13596]	215.522	209.868	1.02694
1151	metaxin 1. [swissprot;acc:q13505]	204.925	199.552	1.02693
1152	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	216.143	221.939	1.02682
1153	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]	216.146	221.93	1.02676
1154	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	230.242	224.307	1.02646
1155	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]
1156	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]
1158	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	216.167	221.877	1.02641
1159	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	165.898	170.28
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	214.041	208.55	1.02633
1161	kappa b-ras 1. [refseq;acc:nm_020345]	215.097	220.758	1.02632
1162	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]
1163	snare associated protein snapin. [refseq;acc:nm_012437]
1164	transducin-like enhancer protein 4. [swissprot;acc:q04727]	213.818	219.438	1.02628
1165	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	213.785	219.401	1.02627
1166	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	213.759	219.374
1167	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	213.784	219.399	1.02626
1168	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]
1170	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]
1171	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]
1172	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	213.767	219.375	1.02623
1173	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	235.246	229.243	1.02619
1174	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	192.849	187.964	1.02599
1175	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	212.672	218.186	1.02593
1176	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]
1179	cellular modulator of immune recognition. [refseq;acc:nm_145021]
1180	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]
1181	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.