Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Network Type I Analysis

Type 1 network in which we propagated the absolute log regulation ratio abs(log(r/g)). We used the filtered lowest boundary of the confidence interval for the microarray measurement based and used the high confidence interaction map. Because type-I networks tend to favour highly connected proteins we tested a normalisation scheme in which we would run the network once with real values (the measured column) and once with simulated values where each measured point is set to 1 instead of the actual signal (the expected column). Afterwards we divided the measured value by the expected value. This normalisation scheme works to a certain extend but will lead to a variance that is directly related to the connectivity of each protein. In the end we dropped the use of Type-I networks due to the many technical problems they pose.


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Rank Gene description measured expected final Hugo
Results: HTML CSV LaTeX Showing element 1708 to 1757 of 3206 in total
Rank
description
measured
expected
final
Hugo
1708 VESICLE-FUSING ATPASE (EC 3.6.4.6) (VESICULAR-FUSION PROTEIN NSF) (N- ETHYLMALEIMIDE SENSITIVE FUSION PROTEIN) (NEM-SENSITIVE FUSION PROTEIN). [SWISSPROT;Acc:P46459] 0.15883 0.66831 0.23765917 NSF
1709 26S PROTEASE REGULATORY SUBUNIT 7 (MSS1 PROTEIN). [SWISSPROT;Acc:P35998] 0.933253 3.92714 0.237641897 PSMC2
1710 60S RIBOSOMAL PROTEIN L4 (L1). [SWISSPROT;Acc:P36578] 0.83123 3.49797 0.237632112 RPL4
1711 0.18248 0.768033 0.237593958 PNPLA7
1712 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11 (26S PROTEASOME REGULATORY SUBUNIT S9) (26S PROTEASOME REGULATORY SUBUNIT P44.5). [SWISSPROT;Acc:O00231] 0.667497 2.81169 0.237400638 PSMD11
1713 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6 (26S PROTEASOME REGULATORY SUBUNIT S10) (P42A) (PROTEASOME REGULATORY PARTICLE SUBUNIT P44S10). [SWISSPROT;Acc:Q15008] 0.750885 3.16322 0.237379948 PSMD6
1714 "NUCLEOLAR PROTEIN FAMILY A, MEMBER 2; COMPONENT OF THE H/ACA SNORNP. [RefSeq;Acc:NM_017838]" 0.0909039 0.382985 0.237356293 NOLA2
1715 "TRANSCRIPTION INITIATION FACTOR IIF, ALPHA SUBUNIT (TFIIF-ALPHA) (TRANSCRIPTION INITIATION FACTOR RAP74). [SWISSPROT;Acc:P35269]" 0.0303013 0.127662 0.237355674 GTF2F1
1716 VACUOLAR PROTON TRANSLOCATING ATPASE 116 KDA SUBUNIT A ISOFORM 1 (CLATHRIN-COATED VESICLE/SYNAPTIC VESICLE PROTON PUMP 116 KDA SUBUNIT) (VACUOLAR PROTON PUMP SUBUNIT 1) (VACUOLAR ADENOSINE TRIPHOSPHATASE SUBUNIT AC116). [SWISSPROT;Acc:Q93050] 0.269961 1.13756 0.237315834 ATP6V0A1
1717 "ATPASE, H+ TRANSPORTING, LYSOSOMAL V0 SUBUNIT A ISOFORM 4; VACUOLAR PROTON PUMP 116 KDA ACCESSORY SUBUNIT; VACUOLAR PROTON PUMP, SUBUNIT 2; H(+)-TRANSPORTING TWO-SECTOR ATPASE, NONCATALYTIC ACCESSORY PROTEIN 1B; ATPASE, H+ TRANSPORTING, LYSOSOMAL (VACUOLA" 0.224133 0.944489 0.237306099 ATP6V0A4
1718 VACUOLAR PROTON TRANSLOCATING ATPASE 116 KDA SUBUNIT A ISOFORM 2 (V-ATPASE 116-KDA ISOFORM A2) (TJ6). [SWISSPROT;Acc:Q9Y487] 0.211834 0.892673 0.237303021 ATP6V0A2
1719 VACUOLAR PROTON TRANSLOCATING ATPASE 116 KDA SUBUNIT A ISOFORM 3 (V- ATPASE 116-KDA ISOFORM A3) (OSTEOCLASTIC PROTON PUMP 116 KDA SUBUNIT) (OC-116 KDA) (OC116) (T-CELL IMMUNE REGULATOR 1) (T CELL IMMUNE RESPONSE CDNA7 PROTEIN) (TIRC7). [SWISSPROT;A 0.202198 0.852079 0.237299593 TCIRG1
1720 MIDASIN (MIDAS-CONTAINING PROTEIN). [SWISSPROT;Acc:Q9NU22] 0.321031 1.35288 0.237294512 MDN1
1721 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9 (26S PROTEASOME REGULATORY SUBUNIT P27). [SWISSPROT;Acc:O00233] 0.154828 0.652697 0.237212673 PSMD9
1722 "PROBABLE DIMETHYLADENOSINE TRANSFERASE (EC 2.1.1.-) (S- ADENOSYLMETHIONINE-6-N',N'-ADENOSYL(RRNA) DIMETHYLTRANSFERASE) (18S RRNA DIMETHYLASE). [SWISSPROT;Acc:Q9UNQ2]" 0.367472 1.54946 0.237161334 DIMT1L
1723 VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 45 (H-VPS45) (HLVPS45). [SWISSPROT;Acc:Q9NRW7] 0.230384 0.971531 0.237134996 VPS45
1724 0.0547796 0.231086 0.237052872 RIOK2
1725 0.10685 0.450769 0.23703937 VPS25
1726 CHMP6
1727 "GLUTAMATE DECARBOXYLASE, 65 KDA ISOFORM (EC 4.1.1.15) (GAD-65) (65 KDA GLUTAMIC ACID DECARBOXYLASE). [SWISSPROT;Acc:Q05329]" 0.0175982 0.0742417 0.237039292 GAD2
1728 0.0787698 0.332307 0.237039244 C12orf26
1729 "GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN (SNAP-GAMMA) (N-ETHYLMALEIMIDE- SENSITIVE FACTOR ATTACHMENT PROTEIN, GAMMA). [SWISSPROT;Acc:Q99747]" 0.056545 0.238547 0.237039242 NAPG
1730 NOSTRIN. [RefSeq;Acc:NM_052946] 0.02137 0.0901539 0.237039108 NOSTRIN
1731 no value
1732 "GLUTAMATE DECARBOXYLASE, 67 KDA ISOFORM (EC 4.1.1.15) (GAD-67) (67 KDA GLUTAMIC ACID DECARBOXYLASE). [SWISSPROT;Acc:Q99259]" 0.0213112 0.0899059 0.237038949 GAD1
1733 "LIV-1 PROTEIN, ESTROGEN REGULATED. [RefSeq;Acc:NM_012319]" 0.0166846 0.0703876 0.23703891 SLC39A6
1734 EAP30 SUBUNIT OF ELL COMPLEX. [RefSeq;Acc:NM_007241] 0.04274 0.180308 0.237038845 SNF8
1735 RAD54-LIKE PROTEIN; RAD54 HOMOLOG. [RefSeq;Acc:NM_003579] 0.180241 0.760447 0.237019805 RAD54L
1736 0.630807 2.66198 0.236969098 ATPBD3
1737 GLUTAMINYL-TRNA SYNTHASE (GLUTAMINE-HYDROLYZING)-LIKE 1. [RefSeq;Acc:NM_018292] 0.094576 0.399107 0.236969033 QRSL1
1738 FATTY-ACID AMIDE HYDROLASE (EC 3.1.-.-) (OLEAMIDE HYDROLASE) (ANANDAMIDE AMIDOHYDROLASE). [SWISSPROT;Acc:O00519] 0.0947181 0.399707 0.23696883 FAAH
1739 "URACIL-DNA GLYCOSYLASE, MITOCHONDRIAL PRECURSOR (EC 3.2.2.-) (UDG). [SWISSPROT;Acc:P13051]" 0.0946707 0.399507 0.236968814 UNG
1740 "PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL PRECURSOR (EC 6.3.5.-) (GLU-ADT SUBUNIT B) (CYTOCHROME OXIDASE ASSEMBLY FACTOR PET112 HOMOLOG). [SWISSPROT;Acc:O75879]" PET112L
1741 COACTOSIN-LIKE PROTEIN. [SWISSPROT;Acc:Q14019] 0.0315727 0.133236 0.236968237 COTL1
1742 CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 6. [SWISSPROT;Acc:Q9Y2V7] 0.0676104 0.2855 0.236814011 COG6
1743 40S RIBOSOMAL PROTEIN S28. [SWISSPROT;Acc:P25112] 0.229236 0.968071 0.236796681 no value
1744 "VACUOLAR ATP SYNTHASE SUBUNIT B, BRAIN ISOFORM (EC 3.6.3.14) (V-ATPASE B2 SUBUNIT) (VACUOLAR PROTON PUMP B ISOFORM 2) (ENDOMEMBRANE PROTON PUMP 58 KDA SUBUNIT) (HO57). [SWISSPROT;Acc:P21281]" 0.357744 1.51127 0.236717463 ATP6V1B2
1745 GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 1-LIKE 1. [RefSeq;Acc:NM_024034] 0.0826697 0.349234 0.236717215 GDAP1L1
1746 YEAST SEC31P HOMOLOG. [RefSeq;Acc:NM_014933] 0.134029 0.566199 0.236717126 SEC31A
1747 VACUOLAR ATP SYNTHASE SUBUNIT E (EC 3.6.3.14) (V-ATPASE E SUBUNIT) (VACUOLAR PROTON PUMP E SUBUNIT) (V-ATPASE 31 KDA SUBUNIT) (P31). [SWISSPROT;Acc:P36543] 0.480242 2.02876 0.236717009 ATP6V1E1
1748 GANGLIOSIDE-INDUCED DIFFERENTIATION-ASSOCIATED PROTEIN 1. [RefSeq;Acc:NM_018972] 0.0973611 0.411298 0.236716687 GDAP1
1749 VACUOLAR ATP SYNTHASE SUBUNIT D (EC 3.6.3.14) (V-ATPASE D SUBUNIT) (VACUOLAR PROTON PUMP D SUBUNIT) (V-ATPASE 28 KDA ACCESSORY PROTEIN). [SWISSPROT;Acc:Q9Y5K8] 0.518099 2.18869 0.236716483 ATP6V1D
1750 VACUOLAR ATP SYNTHASE SUBUNIT H (EC 3.6.3.14) (V-ATPASE H SUBUNIT) (VACUOLAR PROTON PUMP H SUBUNIT) (V-ATPASE 50/57 KDA SUBUNITS) (VACUOLAR PROTON PUMP SUBUNIT SFD) (CGI-11). [SWISSPROT;Acc:Q9UI12] 0.0562476 0.237616 0.236716383 ATP6V1H
1751 VACUOLAR ATP SYNTHASE SUBUNIT G 2 (EC 3.6.3.14) (V-ATPASE G SUBUNIT 2) (VACUOLAR PROTON PUMP G SUBUNIT 2) (V-ATPASE 13 KDA SUBUNIT 2). [SWISSPROT;Acc:O95670] 0.0861167 0.363797 0.236716356 no value
1752 SECRETORY PATHWAY COMPONENT SEC31B-1. [RefSeq;Acc:NM_015490] 0.107954 0.456048 0.236716311 SEC31B
1753 SEC13-RELATED PROTEIN. [SWISSPROT;Acc:P55735] 0.126518 0.534471 0.236716305 SEC13
1754 VACUOLAR ATP SYNTHASE SUBUNIT G 3 (EC 3.6.3.14) (V-ATPASE G SUBUNIT 3) (VACUOLAR PROTON PUMP G SUBUNIT 3) (V-ATPASE 13 KDA SUBUNIT 3). [SWISSPROT;Acc:Q96LB4] 0.0486762 0.205631 0.236716254 ATP6V1G3
1755 APOPTOSIS INHIBITOR 5; FIBROBLAST GROWTH FACTOR 2-INTERACTING FACTOR 2; API5-LIKE 1. [RefSeq;Acc:NM_006595] 0.0646874 0.27327 0.236716068 API5
1756 VACUOLAR ATP SYNTHASE SUBUNIT G 1 (EC 3.6.3.14) (V-ATPASE G SUBUNIT 1) (VACUOLAR PROTON PUMP G SUBUNIT 1) (V-ATPASE 13 KDA SUBUNIT 1) (VACUOLAR ATP SYNTHASE SUBUNIT M16). [SWISSPROT;Acc:O75348] 0.063055 0.266374 0.236716046 ATP6V1G1
1757 0.420128 1.77482 0.236715836 ATP6V1E2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the bloody hugo identifier as demanded by the BMC Bioinformatics idiots
- http://analysis.yellowcouch.org/