MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene	Gene Ontology	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 118 to 167 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.20619	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	biological process	monovalent inorganic cation transport
			potassium ion transport
			proton transport
			sodium ion transport
			sperm motility
			transport
		cellular component	integral to membrane
			membrane
			sodium:potassium-exchanging ATPase complex
		molecular function	ATP binding
			ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
			catalytic activity
			GABA-B receptor activity
			hydrolase activity
			hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
			magnesium ion binding
			monovalent inorganic cation transporter activity
			nucleotide binding
			potassium ion binding
			sodium ion binding
			sodium:potassium-exchanging ATPase activity
1.20924	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	biological process	alcohol metabolic process
			embryonic eye morphogenesis
			lipid metabolic process
			metabolic process
			nucleus accumbens development
			optic cup morphogenesis involved in camera-type eye development
			positive regulation of apoptosis
			retinoic acid metabolic process
		cellular component	cytoplasm
		molecular function	3-chloroallyl aldehyde dehydrogenase activity
			aldehyde dehydrogenase [NAD(P)+] activity
			oxidoreductase activity
1.21384	Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	biological process	metabolic process
		cellular component	nucleus
		molecular function	catalytic activity
			transcription factor binding
1.21871	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	biological process	apoptotic program
			induction of apoptosis
			regulation of apoptosis
		cellular component	integral to membrane
			membrane
			mitochondrial envelope
		molecular function	protein binding
1.23668	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	biological process	biological_process
		cellular component	myosin complex
			unconventional myosin complex
		molecular function	actin binding
			ATP binding
			calmodulin binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.