MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 1501 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.35125	Geminin. [Uniprot/SWISSPROT;Acc:O75496]	biological process	negative regulation of DNA replication
			negative regulation of progression through cell cycle
			organ morphogenesis
			regulation of progression through cell cycle
		cellular component	nucleus
		molecular function	protein binding
1.36997	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]	biological process	angiogenesis
			cell differentiation
			multicellular organismal development
			signal transduction
		cellular component	cell junction
			cytoplasm
			cytoskeleton
			intracellular
			membrane
		molecular function	GTPase activator activity
			protein binding
1.37411	Lariat debranching enzyme (EC 3.1.-.-). [Uniprot/SWISSPROT;Acc:Q9UK59]	biological process	mRNA processing
			nuclear mRNA splicing, via spliceosome
			RNA splicing, via transesterification reactions
		cellular component	nucleus
		molecular function	hydrolase activity
			hydrolase activity, acting on ester bonds
			metal ion binding
			RNA lariat debranching enzyme activity
1.37553	NULL	biological process	protein folding
		molecular function	peptidyl-prolyl cis-trans isomerase activity
1.37801	Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Uniprot/SWISSPROT;Acc:Q9HCC8]	biological process	glycerol metabolic process
			metabolic process
		cellular component	cytoplasm
			cytoskeleton
			integral to membrane
			membrane
		molecular function	glycerophosphodiester phosphodiesterase activity
			hydrolase activity
1.39878	ATPase family AAA domain-containing protein 2B. [Uniprot/SWISSPROT;Acc:Q9ULI0]		ATP binding
			nucleoside-triphosphatase activity
			nucleotide binding
1.40093	NULL		protein binding
1.40602	GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	biological process	ER to Golgi vesicle-mediated transport
			intracellular protein transport
			small GTPase mediated signal transduction
		cellular component	cytoplasm
			endoplasmic reticulum
			Golgi apparatus
			intracellular
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
1.40749	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	biological process	cell adhesion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.