MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Class	Ratio	Regulation	description	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 101 to 150 of 2667 in total

Class  : biological process

Ratio	Regulation	description	Gene Ontology
1.19539	up	Cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7). [Uniprot/SWISSPROT;Acc:Q9Y697]	metabolic process
			protein complex assembly
			sulfur amino acid metabolic process
1.19545		Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	apoptosis
			DNA catabolic process
			DNA metabolic process
			erythrocyte differentiation
			multicellular organismal development
1.20102		Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	apoptosis
			cell cycle
			electron transport
			ion transport
			iron ion transport
1.20481	down	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	biological_process
			generation of precursor metabolites and energy
			ovarian follicle development
			sexual reproduction
1.20619		Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	ATP hydrolysis coupled proton transport
			cation transport
			hydrogen ion homeostasis
			metabolic process
			monovalent inorganic cation transport
			potassium ion transport
			proton transport
			sodium ion transport
			sperm motility
			transport
1.20924		Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	alcohol metabolic process
			embryonic eye morphogenesis
			lipid metabolic process
			metabolic process
			nucleus accumbens development
			optic cup morphogenesis involved in camera-type eye development
			positive regulation of apoptosis
			retinoic acid metabolic process
1.21384		Disco-interacting protein 2 homolog C. [Uniprot/SWISSPROT;Acc:Q9Y2E4]	metabolic process
1.21657	up	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	cell cycle
			cytokinesis
			positive regulation of exocytosis
			regulation of exocytosis
			small GTPase mediated signal transduction
			synaptic vesicle targeting
1.21698		Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	electron transport
			metabolic process
1.21705		T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]	cellular protein metabolic process
			protein amino acid phosphorylation
			protein folding
			regulation of progression through cell cycle
1.21871	down	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	apoptotic program
			induction of apoptosis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.