MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	Class	description	Gene	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 800 to 849 of 2667 in total

Ratio	Regulation	Class	description	Gene Ontology
1.30869	down	biological process	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	ubiquitin cycle
				ubiquitin-dependent protein catabolic process
		cellular component		cellular_component
				nucleus
		molecular function		ligase activity
				metal ion binding
				protein binding
				ubiquitin-protein ligase activity
				zinc ion binding
1.31489		cellular component	Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	intracellular
		molecular function		metal ion binding
				protein binding
				zinc ion binding
1.31661	up	biological process	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	anion transport
				cytochrome complex assembly
				excretion
				heme transport
				sulfate transport
				transport
		cellular component		apical plasma membrane
				brush border membrane
				integral to membrane
				membrane
				membrane fraction
		molecular function		anion exchanger activity
				antiporter activity
				chloride ion binding
				heme transporter activity
				sulfate porter activity
				transcription cofactor activity
				transcription factor activity
				transporter activity
1.31895			Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]	receptor activity
1.32602	down	biological process	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	protein metabolic process
		molecular function		oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
1.33329	up	biological process	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	carbohydrate metabolic process
				glycoprotein catabolic process
				metabolic process
				protein modification process
		cellular component		lysosome
		molecular function		beta-mannosidase activity
				cation binding
				hydrolase activity, hydrolyzing O-glycosyl compounds
1.33465		biological process	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	cell-cell signaling
				embryonic arm morphogenesis
				embryonic limb morphogenesis
				forelimb morphogenesis
				heart development
				induction of apoptosis
				lung development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.