MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 1501 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.12417	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	retinoic acid receptor binding	molecular function
		retinoid-X receptor activity
		thyroid hormone receptor binding
		thyroid hormone receptor coactivator activity
		vitamin D receptor binding
1.13007	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	anion transport	biological process
		G-protein coupled receptor protein signaling pathway
		histamine receptor activity	molecular function
		inorganic anion exchanger activity
		integral to membrane	cellular component
		intracellular
		membrane
		metal ion binding	molecular function
		nucleic acid binding
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		transcription factor activity	molecular function
		zinc ion binding
1.14915	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	cell-cell signaling	biological process
		integral to membrane	cellular component
		membrane
		receptor binding	molecular function
		signal transduction	biological process
		transport
1.15279	Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	cell adhesion
		glycosaminoglycan binding	molecular function
		integral to plasma membrane	cellular component
		membrane
		protein binding	molecular function
		structural molecule activity
		viral capsid	cellular component
1.16158	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [RefSeq_dna;Acc:NR_002720]	calcium channel activity	molecular function
		calcium ion transport	biological process
		ion channel activity	molecular function
		ion transport	biological process
		membrane	cellular component
1.16173	oligonucleotide/oligosaccharide-binding fold containing 2B [RefSeq_peptide;Acc:NP_076973]	nucleic acid binding	molecular function
1.16363	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Uniprot/SWISSPROT;Acc:Q9HBV2]	integral to membrane	cellular component
		membrane
1.16393	olfactory receptor, family 5, subfamily K, member 4 [RefSeq_peptide;Acc:NP_001005517]	G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
		olfactory receptor activity	molecular function
		rhodopsin-like receptor activity
1.16499	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	cell adhesion	biological process
		central nervous system development
		integral to membrane	cellular component
		integrin binding	molecular function
		membrane	cellular component
		metalloendopeptidase activity	molecular function
		negative regulation of cell adhesion	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.