MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

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Showing element 1069 to 1118 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
4.50619	Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	biological process	apoptosis
			phagocytosis
		cellular component	cytoplasm
			cytoskeleton
			membrane
4.62042	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	biological process	protein amino acid N-linked glycosylation
			visual perception
		cellular component	integral to membrane
			integral to plasma membrane
			membrane
			plasma membrane
4.69231	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	biological process	metabolic process
		cellular component	cytoplasm
		molecular function	acetyltransferase activity
			arylamine N-acetyltransferase activity
			transferase activity
4.71132	Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	biological process	glycolysis
			response to other organism
		cellular component	cellular_component
		molecular function	magnesium ion binding
			potassium ion binding
			pyruvate kinase activity
			transferase activity
4.90535	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]		protein binding
4.93372	Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	biological process	intracellular signaling cascade
5.23046	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]		G-protein coupled receptor protein signaling pathway
			negative regulation of apoptosis
			phosphoinositide phosphorylation
			phosphoinositide-mediated signaling
			protein amino acid phosphorylation
		cellular component	phosphoinositide 3-kinase complex
		molecular function	1-phosphatidylinositol-3-kinase activity
			inositol or phosphatidylinositol kinase activity
			phosphatidylinositol-4,5-bisphosphate 3-kinase activity
			phosphotransferase activity, alcohol group as acceptor
			protein binding
			transferase activity
5.32612	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	biological process	cellular respiration
			heart development
			inflammatory response
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
		cellular component	cytoplasm
			nucleus
		molecular function	protein binding
			transcription coactivator activity
			transcription factor activity
5.61927	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	biological process	transport
		cellular component	integral to membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.