MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1951 to 2000 of 2667 in total

Regulation  : up

description	Ratio	Class	Gene Ontology
Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]	4.55371	cellular component	integral to membrane
			integral to plasma membrane
			membrane
			nucleus
		molecular function	G-protein coupled receptor activity
			parathyroid hormone receptor activity
			receptor activity
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein). [Uniprot/SWISSPROT;Acc:Q96JY6]	5.81102	cellular component	cell surface
			cytoplasm
			cytoskeleton
			nucleus
		molecular function	metal ion binding
			protein binding
			zinc ion binding
Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Uniprot/SWISSPROT;Acc:Q9H4M7]	1.17693	biological process	biological_process
		cellular component	cellular_component
			cytoplasm
			membrane
		molecular function	lipid binding
			phosphatidylinositol binding
Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	1.15279	biological process	cell adhesion
		cellular component	integral to plasma membrane
			membrane
			viral capsid
		molecular function	glycosaminoglycan binding
			protein binding
			structural molecule activity
Poliovirus receptor-related protein 3 precursor (Nectin-3) (CD113 antigen) (CDw113). [Uniprot/SWISSPROT;Acc:Q9NQS3]	1.4628	biological process	cell adhesion
			homophilic cell adhesion
		cellular component	apical junction complex
			cell-cell adherens junction
			integral to membrane
			plasma membrane
		molecular function	protein binding
			protein homodimerization activity
			receptor activity
Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]	4.67988	biological process	dicarboxylic acid transport
			ion transport
			potassium ion transport
		cellular component	integral to membrane
			membrane
			membrane fraction
			voltage-gated potassium channel complex
		molecular function	delayed rectifier potassium channel activity
			ion channel activity
			outward rectifier potassium channel activity
			potassium ion binding
			protein binding
			sodium:dicarboxylate symporter activity
			voltage-gated ion channel activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.