Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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description Ratio Regulation Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
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Showing element 1 to 50 of 2667 in total
description	Ratio	Regulation	Class	Gene Ontology	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	negative regulation of protein kinase activity	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	protein targeting	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	regulation of neuron differentiation	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	regulation of signal transduction	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	biological process	regulation of synaptic plasticity	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	cellular component	cytoplasm	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	molecular function	insulin-like growth factor receptor binding	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	molecular function	protein domain specific binding	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	molecular function	protein kinase C binding	
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	1.14311	down	molecular function	protein kinase C inhibitor activity	
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Source:Uniprot/SWISSPROT;Acc:P82673]	2.61135	down	biological process	DNA damage response, detection of DNA damage	
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Source:Uniprot/SWISSPROT;Acc:P82673]	2.61135	down	biological process	peptide biosynthetic process	
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Source:Uniprot/SWISSPROT;Acc:P82673]	2.61135	down	cellular component	mitochondrial small ribosomal subunit	
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Source:Uniprot/SWISSPROT;Acc:P82673]	2.61135	down	cellular component	mitochondrion	
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Source:Uniprot/SWISSPROT;Acc:P82673]	2.61135	down	cellular component	ribonucleoprotein complex	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	biological process	translation	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	cellular component	intracellular	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	cellular component	large ribosomal subunit	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	cellular component	mitochondrion	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	cellular component	ribosome	
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Source:Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	down	molecular function	structural constituent of ribosome	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	biological process	translation	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	cellular component	cytosolic small ribosomal subunit (sensu Eukaryota)	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	cellular component	intracellular	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	cellular component	ribosome	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	cellular component	small ribosomal subunit	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	molecular function	RNA binding	
40S ribosomal protein S2 (S4) (LLRep3 protein). [Source:Uniprot/SWISSPROT;Acc:P15880]	2.45383	down	molecular function	structural constituent of ribosome	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	biological process	cell adhesion	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	biological process	myoblast fusion	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	biological process	proteolysis	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	cellular component	integral to membrane	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	cellular component	plasma membrane	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	molecular function	metal ion binding	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	molecular function	metalloendopeptidase activity	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	molecular function	metallopeptidase activity	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	molecular function	protein binding	
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184]	1.76994	down	molecular function	zinc ion binding	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	biological process	cell adhesion	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	biological process	central nervous system development	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	biological process	negative regulation of cell adhesion	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	biological process	proteolysis	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	cellular component	integral to membrane	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	cellular component	membrane	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	molecular function	integrin binding	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	molecular function	metalloendopeptidase activity	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	molecular function	protein binding	
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	up	molecular function	zinc ion binding	
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [Source:RefSeq_peptide;Acc:NP_055087]	1.28805	down	biological process	proteolysis	
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [Source:RefSeq_peptide;Acc:NP_055087]	1.28805	down	cellular component	extracellular matrix	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.
- http://analysis.yellowcouch.org/