Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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description Ratio Regulation Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 2667 in total

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\begin{longtable}{|c|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Regulation\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Class\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\multirow{10}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). \vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
1.14311\vspace{3pt}}}&\multirow{38}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\multirow{5}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
negative regulation of protein kinase activity\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein targeting\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
regulation of neuron differentiation\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
regulation of signal transduction\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
regulation of synaptic plasticity\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-5}
&&&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
insulin-like growth factor receptor binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein domain specific binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein kinase C binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein kinase C inhibitor activity\vspace{3pt}}\\\cline{1-2}\cline{4-5}
\multirow{5}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). \vspace{3pt}}}&\multirow{5}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
2.61135\vspace{3pt}}}&&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
DNA damage response, detection of DNA damage\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
peptide biosynthetic process\vspace{3pt}}\\\cline{4-5}
&&&\multirow{3}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
mitochondrial small ribosomal subunit\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
mitochondrion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
ribonucleoprotein complex\vspace{3pt}}\\\cline{1-2}\cline{4-5}
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). \vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
2.16131\vspace{3pt}}}&&\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
translation\vspace{3pt}}\\\cline{4-5}
&&&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
large ribosomal subunit\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
mitochondrion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
ribosome\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
structural constituent of ribosome\vspace{3pt}}\\\cline{1-2}\cline{4-5}
\multirow{7}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
40S ribosomal protein S2 (S4) (LLRep3 protein). \vspace{3pt}}}&\multirow{7}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
2.45383\vspace{3pt}}}&&\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
translation\vspace{3pt}}\\\cline{4-5}
&&&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
cytosolic small ribosomal subunit (sensu Eukaryota)\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
intracellular\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
ribosome\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
small ribosomal subunit\vspace{3pt}}\\\cline{4-5}
&&&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
RNA binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
structural constituent of ribosome\vspace{3pt}}\\\cline{1-2}\cline{4-5}
\multirow{10}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). \vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
1.76994\vspace{3pt}}}&&\multirow{3}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
myoblast fusion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}\\\cline{4-5}
&&&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
plasma membrane\vspace{3pt}}\\\cline{4-5}
&&&\multirow{5}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
metal ion binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
metalloendopeptidase activity\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
metallopeptidase activity\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
\multirow{10}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). \vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
1.16499\vspace{3pt}}}&\multirow{10}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
up\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
cell adhesion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
central nervous system development\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
negative regulation of cell adhesion\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}\\\cline{4-5}
&&&\multirow{2}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{4-5}
&&&\multirow{4}{*}{\parbox{\wcD}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcE}{\vspace{3pt}\noindent
integrin binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
metalloendopeptidase activity\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
protein binding\vspace{3pt}}\\\cline{5-5}
&&&&\parbox{\wcE}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
1.28805\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
down\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
proteolysis\vspace{3pt}}\\\cline{4-5}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcE}{\vspace{3pt}\noindent
extracellular matrix\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/