MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Minimum Ratio	Gene	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1455 to 1504 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.66679	up	TCDD-inducible poly [ADP-ribose] polymerase (EC 2.4.2.30) (Poly [ADP- ribose] polymerase 7) (PARP-7). [Uniprot/SWISSPROT;Acc:Q7Z3E1]	transferase activity, transferring glycosyl groups	molecular function
			zinc ion binding
1.683	down	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	cytoplasm	cellular component
			exonuclease activity	molecular function
			exosome (RNase complex)	cellular component
			GDP-dissociation stimulator activity	molecular function
			hydrolase activity
			nucleus	cellular component
			ribonuclease activity	molecular function
			RNA binding
			rRNA processing	biological process
1.69153		Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	intermediate filament	cellular component
1.693		CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	catalytic activity	molecular function
			iron-sulfur cluster binding
			metabolic process	biological process
1.69345	up	GC-rich sequence DNA-binding factor (GCF) (Transcription factor 9) (TCF-9). [Uniprot/SWISSPROT;Acc:P16383]	DNA binding	molecular function
			nucleus	cellular component
			regulation of transcription	biological process
			regulation of transcription, DNA-dependent
			RNA polymerase II transcription factor activity	molecular function
			transcription factor activity
1.69658	down	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	beta-galactoside alpha-2,3-sialyltransferase activity
			Golgi apparatus	cellular component
			integral to Golgi membrane
			integral to membrane
			membrane
			protein amino acid glycosylation	biological process
			sialyltransferase activity	molecular function
			transferase activity, transferring glycosyl groups
1.69856	up	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2). [Uniprot/SWISSPROT;Acc:Q9H1R3]	ATP binding
			calmodulin binding
			cytoplasm	cellular component
			neuromuscular synaptic transmission	biological process
			nucleotide binding	molecular function
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
1.72628	down	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	DNA repair	biological process
			integral to membrane	cellular component
			membrane
			methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular function
			structural molecule activity
1.72656		protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	ER overload response	biological process
			protein phosphatase type 1 complex	cellular component
			protein serine/threonine phosphatase activity	molecular function
			response to hydrogen peroxide	biological process
			response to oxidative stress
1.73211		Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	ATP binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.