Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio Regulation description Class Gene Accession Gene Ontology Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 20 of 20 in total
Class: biological process
Gene Ontology: G-protein coupled receptor protein signaling pathway
\def\wcA{0.25\textwidth} \def\wcB{0.25\textwidth} \def\wcC{0.25\textwidth} \begin{longtable}{|c|c|c|} \hline \parbox{\wcA}{\vspace{3pt}\noindent Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent Regulation\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent description\vspace{3pt}}\\ \hline \hline \parbox{\wcA}{\vspace{3pt}\noindent 1.07618\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.13007\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Zinc finger protein 219. \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.16393\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent olfactory receptor, family 5, subfamily K, member 4 \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.19117\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Ras-related GTP-binding protein D (Rag D). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.27461\vspace{3pt}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Homeobox protein Hox-D3 (Hox-4A). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.351\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent TBK1 binding protein 1 \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.36911\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.40749\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent collagen, type XXVII, alpha 1 \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.51342\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Beta-defensin 2 precursor (BD-2) (hBD-2) (Defensin, beta 2) (Skin- antimicrobial peptide 1) (SAP1). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 1.61987\vspace{3pt}}&\multirow{5}{*}{\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.6384\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Olfactory receptor 6S1. \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.66123\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent KRAB-A domain containing 1 (KRBA1), mRNA \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.83601\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent coiled-coil domain containing 90A \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 1.93863\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 2.44552\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 2.86538\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent up\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). \vspace{3pt}}\\\hline \parbox{\wcA}{\vspace{3pt}\noindent 3.52215\vspace{3pt}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent down\vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent Olfactory receptor 4L1 (Olfactory receptor OR14-28). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 3.54799\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 5.23046\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). \vspace{3pt}}\\\cline{1-1}\cline{3-3} \parbox{\wcA}{\vspace{3pt}\noindent 7.45006\vspace{3pt}}&&\parbox{\wcC}{\vspace{3pt}\noindent MAP7 domain containing 1 \vspace{3pt}}\\\hline nd{longtable}
Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

- http://analysis.yellowcouch.org/