MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 18 to 67 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.10831	up	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	molecular function	collagen binding
1.10867		Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	biological process	adenohypophysis development
				cell-cell signaling
				elevation of cytosolic calcium ion concentration
				G-protein signaling, adenylate cyclase activating pathway
				growth hormone secretion
				positive regulation of body size
				positive regulation of cAMP metabolic process
				positive regulation of growth hormone secretion
				positive regulation of hormone secretion
				positive regulation of transcription
				signal transduction
			cellular component	extracellular region
				terminal button
			molecular function	growth hormone-releasing hormone activity
				growth hormone-releasing hormone receptor binding
				hormone activity
1.10889		Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	protein dimerization activity
				sequence-specific DNA binding
				transcription factor activity
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]	biological process	neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
				plasma membrane
			molecular function	neurotransmitter:sodium symporter activity
				symporter activity
				transporter activity
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	biological process	translational initiation
			cellular component	cytoplasm
			molecular function	RNA binding
				translation initiation factor activity
1.11956	down	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]	biological process	retrograde vesicle-mediated transport, Golgi to ER
			cellular component	Golgi apparatus
				integral to Golgi membrane
				integral to membrane
				membrane
			molecular function	molecular_function
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	biological process	protein homooligomerization
				protein localization
				response to metal ion
			cellular component	membrane
			molecular function	enzyme binding
				protein heterodimerization activity
				retinoic acid receptor binding
				retinoid-X receptor activity
				thyroid hormone receptor binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.