Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 688 in total

Class	cellular component

Ratio	Regulation	description	Gene Ontology	
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	integral to membrane	
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	nucleus	
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	ribonucleoprotein complex	
1.07618	up	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Source:Uniprot/SWISSPROT;Acc:Q15696]	U12-dependent spliceosome	
1.10233	up	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	cytoplasm	
1.10233	up	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Source:Uniprot/SWISSPROT;Acc:Q99501]	cytoskeleton	
1.10867	up	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	extracellular region	
1.10867	up	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Source:Uniprot/SWISSPROT;Acc:P01286]	terminal button	
1.10889	up	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	cytoplasm	
1.10889	up	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Source:Uniprot/SWISSPROT;Acc:Q96F24]	nucleus	
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	integral to plasma membrane	
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	membrane	
1.11083	down	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Source:Uniprot/SWISSPROT;Acc:Q9NP91]	plasma membrane	
1.11519	up	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [Source:RefSeq_dna;Acc:NM_001099408]	cytoplasm	
1.11956	down	Protein RER1. [Source:Uniprot/SWISSPROT;Acc:O15258]	Golgi apparatus	
1.11956	down	Protein RER1. [Source:Uniprot/SWISSPROT;Acc:O15258]	integral to Golgi membrane	
1.11956	down	Protein RER1. [Source:Uniprot/SWISSPROT;Acc:O15258]	integral to membrane	
1.11956	down	Protein RER1. [Source:Uniprot/SWISSPROT;Acc:O15258]	membrane	
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Source:Uniprot/SWISSPROT;Acc:O60888]	membrane	
1.1243	down	Zinc finger protein basonuclin-2. [Source:Uniprot/SWISSPROT;Acc:Q6ZN30]	intracellular	
1.1243	down	Zinc finger protein basonuclin-2. [Source:Uniprot/SWISSPROT;Acc:Q6ZN30]	nucleus	
1.13007	up	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	integral to membrane	
1.13007	up	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	intracellular	
1.13007	up	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	membrane	
1.13007	up	Zinc finger protein 219. [Source:Uniprot/SWISSPROT;Acc:Q9P2Y4]	nucleus	
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Source:Uniprot/SWISSPROT;Acc:Q99435]	extracellular region	
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Source:Uniprot/SWISSPROT;Acc:Q99435]	membrane	
1.14311	down	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Source:Uniprot/SWISSPROT;Acc:P61981]	cytoplasm	
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Source:Uniprot/SWISSPROT;Acc:Q13445]	integral to membrane	
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Source:Uniprot/SWISSPROT;Acc:Q13445]	membrane	
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Source:Uniprot/SWISSPROT;Acc:Q9NZ53]	integral to plasma membrane	
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Source:Uniprot/SWISSPROT;Acc:Q9NZ53]	membrane	
1.15279	up	Podocalyxin-like protein 2 precursor (Endoglycan). [Source:Uniprot/SWISSPROT;Acc:Q9NZ53]	viral capsid	
1.1611	down	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Source:Uniprot/SWISSPROT;Acc:Q02747]	extracellular region	
1.16158	up	transient receptor potential cation channel, subfamily C, member 2 (TRPC2) on chromosome 11 [Source:RefSeq_dna;Acc:NR_002720]	membrane	
1.16363	up	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Source:Uniprot/SWISSPROT;Acc:Q9HBV2]	integral to membrane	
1.16363	up	Sperm acrosome membrane-associated protein 1 precursor (Sperm acrosomal membrane-associated protein 32). [Source:Uniprot/SWISSPROT;Acc:Q9HBV2]	membrane	
1.16393	up	olfactory receptor, family 5, subfamily K, member 4 [Source:RefSeq_peptide;Acc:NP_001005517]	integral to membrane	
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	integral to membrane	
1.16499	up	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Source:Uniprot/SWISSPROT;Acc:Q9P0K1]	membrane	
1.16921	up	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Source:Uniprot/SWISSPROT;Acc:Q96HZ4]	nucleus	
1.16921	up	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1). [Source:Uniprot/SWISSPROT;Acc:Q96HZ4]	transcription factor complex	
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Source:Uniprot/SWISSPROT;Acc:O75356]	endoplasmic reticulum	
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Source:Uniprot/SWISSPROT;Acc:O75356]	integral to membrane	
1.17398	up	Ectonucleoside triphosphate diphosphohydrolase 5 precursor (EC 3.6.1.6) (NTPDase 5) (Nucleoside diphosphatase) (CD39 antigen-like 4) (ER-UDPase). [Source:Uniprot/SWISSPROT;Acc:O75356]	membrane	
1.17693	up	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Source:Uniprot/SWISSPROT;Acc:Q9H4M7]	cellular_component	
1.17693	up	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Source:Uniprot/SWISSPROT;Acc:Q9H4M7]	cytoplasm	
1.17693	up	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1). [Source:Uniprot/SWISSPROT;Acc:Q9H4M7]	membrane	
1.17859	down	XK-related protein 5. [Source:Uniprot/SWISSPROT;Acc:Q6UX68]	integral to membrane	
1.17859	down	XK-related protein 5. [Source:Uniprot/SWISSPROT;Acc:Q6UX68]	membrane	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/