MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Gene	Class	description	Ratio	Accession	Gene Ontology	Regulation	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Class  : biological process

description	Ratio	Gene Ontology	Regulation
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	1.14311	negative regulation of protein kinase activity	down
		protein targeting
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	2.61135	DNA damage response, detection of DNA damage
		peptide biosynthetic process
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	2.16131	translation
40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	2.45383
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]	1.76994	cell adhesion
		myoblast fusion
		proteolysis
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	cell adhesion	up
		central nervous system development
		negative regulation of cell adhesion
		proteolysis
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	1.28805		down
ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	2.45875		up
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	5.19755	fatty acid oxidation
		hormone-mediated signaling
		lipid metabolic process
Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]	1.20924	alcohol metabolic process	down
		embryonic eye morphogenesis
		lipid metabolic process
		metabolic process
		nucleus accumbens development
		optic cup morphogenesis involved in camera-type eye development
		positive regulation of apoptosis
		retinoic acid metabolic process
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	4.40797	alcohol metabolic process
		carbohydrate metabolic process
		metabolic process
		neuropeptide signaling pathway
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	nervous system development	up
		protein transport
Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	2.88235	anion transport	down
Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	4.93372	intracellular signaling cascade
Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	1.73211	cell cycle
		cell proliferation
		meiosis
		regulation of progression through cell cycle
AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	4.07995	insulin receptor signaling pathway	up
		intracellular protein transport
		protein complex assembly
		transport
		vesicle-mediated transport
AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	1.50284	intracellular protein transport	down
		protein complex assembly
		transport
		vesicle-mediated transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.