MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2069 to 2118 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	2.31699	down	molecular function	manganese ion binding
				metal ion binding
				phosphoprotein phosphatase activity
				protein binding
				protein phosphatase type 2A activity
Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2). [Uniprot/SWISSPROT;Acc:O14830]	1.59819	up	biological process	detection of stimulus during sensory perception
				protein amino acid dephosphorylation
				response to stimulus
				visual perception
			molecular function	calcium ion binding
				hydrolase activity
				iron ion binding
				manganese ion binding
				phosphoprotein phosphatase activity
				protein serine/threonine phosphatase activity
SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	2.83611	down	biological process	negative regulation of cell growth
				positive regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
			cellular component	nucleus
			molecular function	protein binding
				transcriptional activator activity
SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP). [Uniprot/SWISSPROT;Acc:Q9Y566]	2.07532	up	biological process	cytoskeletal anchoring
			cellular component	cell junction
				cytoplasm
				dendrite
				intracellular
				membrane fraction
				postsynaptic membrane
				synapse
			molecular function	protein binding
Short palate, lung and nasal epithelium carcinoma-associated protein 3 precursor. [Uniprot/SWISSPROT;Acc:Q9BQP9]	7.27043			lipid binding
Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]	1.96673		biological process	proteolysis
				signal peptide processing
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
				microsome
			molecular function	peptidase activity
				serine-type peptidase activity
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	1.40552	down	biological process	amino acid metabolic process
				amino acid transport
				dicarboxylic acid transport
				neurotransmitter transport
			cellular component	integral to plasma membrane
				membrane
			molecular function	amino acid transporter activity
				neurotransmitter:sodium symporter activity
				sodium:dicarboxylate symporter activity
				symporter activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.