MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 1501 in total

Regulation  : up

Ratio	description	Class	Gene Ontology
1.07618	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	biological process	G-protein coupled receptor protein signaling pathway
			RNA splicing
		cellular component	integral to membrane
			nucleus
			ribonucleoprotein complex
			U12-dependent spliceosome
		molecular function	metal ion binding
			nucleic acid binding
			nucleotide binding
			rhodopsin-like receptor activity
			RNA binding
			zinc ion binding
1.10233	GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). [Uniprot/SWISSPROT;Acc:Q99501]	biological process	cell cycle arrest
		cellular component	cytoplasm
			cytoskeleton
1.10831	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). [Uniprot/SWISSPROT;Acc:Q15113]	biological process	multicellular organismal development
		molecular function	collagen binding
1.10867	Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). [Uniprot/SWISSPROT;Acc:P01286]	biological process	adenohypophysis development
			cell-cell signaling
			elevation of cytosolic calcium ion concentration
			G-protein signaling, adenylate cyclase activating pathway
			growth hormone secretion
			positive regulation of body size
			positive regulation of cAMP metabolic process
			positive regulation of growth hormone secretion
			positive regulation of hormone secretion
			positive regulation of transcription
			signal transduction
		cellular component	extracellular region
			terminal button
		molecular function	growth hormone-releasing hormone activity
			growth hormone-releasing hormone receptor binding
			hormone activity
1.10889	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). [Uniprot/SWISSPROT;Acc:Q96F24]	biological process	regulation of transcription, DNA-dependent
			transcription
		cellular component	cytoplasm
			nucleus
		molecular function	protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
1.11519	eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA [RefSeq_dna;Acc:NM_001099408]	biological process	translational initiation
		cellular component	cytoplasm
		molecular function	RNA binding
			translation initiation factor activity
1.12417	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	biological process	protein homooligomerization
			protein localization
			response to metal ion
		cellular component	membrane
		molecular function	enzyme binding
			protein heterodimerization activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.