Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation description Class Gene Ontology Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1 to 50 of 1501 in total
Regulation: up

\def\wcA{0.2\textwidth}
\def\wcB{0.2\textwidth}
\def\wcC{0.2\textwidth}
\def\wcD{0.2\textwidth}
\begin{longtable}{|c|c|c|c|}
\hline
\parbox{\wcA}{\vspace{3pt}\noindent
Ratio\vspace{3pt}}&\parbox{\wcB}{\vspace{3pt}\noindent
description\vspace{3pt}}&\parbox{\wcC}{\vspace{3pt}\noindent
Class\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
Gene Ontology\vspace{3pt}}\\
\hline
\hline
\multirow{12}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.07618\vspace{3pt}}}&\multirow{12}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein coupled receptor protein signaling pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
RNA splicing\vspace{3pt}}\\\cline{3-4}
&&\multirow{4}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
integral to membrane\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
ribonucleoprotein complex\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
U12-dependent spliceosome\vspace{3pt}}\\\cline{3-4}
&&\multirow{6}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
metal ion binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleic acid binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleotide binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
rhodopsin-like receptor activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
RNA binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
zinc ion binding\vspace{3pt}}\\\hline
\multirow{3}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10233\vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
GAS2-like protein 1 (Growth arrest-specific 2-like 1) (GAS2-related protein on chromosome 22) (GAR22 protein). \vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cell cycle arrest\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cytoskeleton\vspace{3pt}}\\\hline
\multirow{2}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10831\vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein). \vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
multicellular organismal development\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
collagen binding\vspace{3pt}}\\\hline
\multirow{16}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10867\vspace{3pt}}}&\multirow{16}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Somatoliberin precursor (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin). \vspace{3pt}}}&\multirow{11}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
adenohypophysis development\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
cell-cell signaling\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
elevation of cytosolic calcium ion concentration\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
G-protein signaling, adenylate cyclase activating pathway\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
growth hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of body size\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of cAMP metabolic process\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of growth hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of hormone secretion\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
positive regulation of transcription\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
signal transduction\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
extracellular region\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
terminal button\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
growth hormone-releasing hormone activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
growth hormone-releasing hormone receptor binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
hormone activity\vspace{3pt}}\\\hline
\multirow{7}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.10889\vspace{3pt}}}&\multirow{7}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR). \vspace{3pt}}}&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
regulation of transcription, DNA-dependent\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
nucleus\vspace{3pt}}\\\cline{3-4}
&&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
protein dimerization activity\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
sequence-specific DNA binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
transcription factor activity\vspace{3pt}}\\\hline
\multirow{4}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.11519\vspace{3pt}}}&\multirow{4}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
eukaryotic translation initiation factor 4E family member 1B (EIF4E1B), mRNA \vspace{3pt}}}&\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
translational initiation\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
cytoplasm\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
RNA binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
translation initiation factor activity\vspace{3pt}}\\\hline
\multirow{6}{*}{\parbox{\wcA}{\vspace{3pt}\noindent
1.12417\vspace{3pt}}}&\multirow{6}{*}{\parbox{\wcB}{\vspace{3pt}\noindent
Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). \vspace{3pt}}}&\multirow{3}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
biological process\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
protein homooligomerization\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein localization\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
response to metal ion\vspace{3pt}}\\\cline{3-4}
&&\parbox{\wcC}{\vspace{3pt}\noindent
cellular component\vspace{3pt}}&\parbox{\wcD}{\vspace{3pt}\noindent
membrane\vspace{3pt}}\\\cline{3-4}
&&\multirow{2}{*}{\parbox{\wcC}{\vspace{3pt}\noindent
molecular function\vspace{3pt}}}&\parbox{\wcD}{\vspace{3pt}\noindent
enzyme binding\vspace{3pt}}\\\cline{4-4}
&&&\parbox{\wcD}{\vspace{3pt}\noindent
protein heterodimerization activity\vspace{3pt}}\\\hline
nd{longtable}

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.

 - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 

 - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 

 - The Gene Ontology terms as linked to the specific gene.

 - Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray

 - Accession is the GO accession key. 

 - Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.

 - Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/