Scientific

MK5 Microarray Data


Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Ratio description Gene Regulation Class Accession Gene Ontology Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 45 of 45 in total
Regulation	down
Class molecular function
Gene Ontology protein binding
Ratio description 1.08658 pyrin and HIN domain family, member 1 alpha 1 isoform [Source:RefSeq_peptide;Acc:NP_689714] 1.13541 Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Source:Uniprot/SWISSPROT;Acc:Q99435] 1.18096 Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Source:Uniprot/SWISSPROT;Acc:P35354] 1.21871 Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Source:Uniprot/SWISSPROT;Acc:Q13323] 1.23845 Insulin-induced gene 1 protein (INSIG-1). [Source:Uniprot/SWISSPROT;Acc:O15503] 1.24964 Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Source:Uniprot/SWISSPROT;Acc:Q8NHH9] 1.27696 Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Source:Uniprot/SWISSPROT;Acc:Q5MJ70] 1.27802 Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Source:Uniprot/SWISSPROT;Acc:O15479] 1.28356 T-box transcription factor TBX2 (T-box protein 2). [Source:Uniprot/SWISSPROT;Acc:Q13207] 1.30207 Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Source:Uniprot/SWISSPROT;Acc:Q5SW96] 1.30869 E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Source:Uniprot/SWISSPROT;Acc:Q96EP1] 1.31489 Tripartite motif-containing protein 58 (Protein BIA2). [Source:Uniprot/SWISSPROT;Acc:Q8NG06] 1.33817 Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Source:Uniprot/SWISSPROT;Acc:Q9H0R8] 1.42215 Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Source:Uniprot/SWISSPROT;Acc:P31645] 1.48363 Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Source:Uniprot/SWISSPROT;Acc:P30291] 1.48389 Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Source:Uniprot/SWISSPROT;Acc:P49790] 1.49271 Cullin-4B (CUL-4B). [Source:Uniprot/SWISSPROT;Acc:Q13620] 1.49558 Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Source:Uniprot/SWISSPROT;Acc:P12643] 1.49923 Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Source:Uniprot/SWISSPROT;Acc:Q13905] 1.50284 AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Source:Uniprot/SWISSPROT;Acc:P59780] 1.50715 F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Source:Uniprot/SWISSPROT;Acc:Q969U6] 1.58045 Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Source:Uniprot/SWISSPROT;Acc:P56589] 1.61347 Calmodulin-like protein 5 (Calmodulin-like skin protein). [Source:Uniprot/SWISSPROT;Acc:Q9NZT1] 1.73211 Antigen KI-67. [Source:Uniprot/SWISSPROT;Acc:P46013] 1.76994 ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Source:Uniprot/SWISSPROT;Acc:O43184] 1.80858 Rhophilin-1 (GTP-Rho-binding protein 1). [Source:Uniprot/SWISSPROT;Acc:Q8TCX5] 1.98137 Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Source:Uniprot/SWISSPROT;Acc:P35398] 2.31699 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Source:Uniprot/SWISSPROT;Acc:P62714] 2.33107 F-box only protein 15. [Source:Uniprot/SWISSPROT;Acc:Q8NCQ5] 2.79087 leucine-rich repeat neuronal 6A [Source:RefSeq_peptide;Acc:NP_116197] 2.83611 SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Source:Uniprot/SWISSPROT;Acc:Q9UJW9] 2.93895 TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Source:Uniprot/SWISSPROT;Acc:Q92844] 3.05037 Thrombospondin-4 precursor. [Source:Uniprot/SWISSPROT;Acc:P35443] 3.29064 Transcription factor GATA-6 (GATA-binding factor 6). [Source:Uniprot/SWISSPROT;Acc:Q92908] 3.43019 Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Source:Uniprot/SWISSPROT;Acc:O95926] 3.54799 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Source:Uniprot/SWISSPROT;Acc:P62879] 3.71868 Protein pelota homolog. [Source:Uniprot/SWISSPROT;Acc:Q9BRX2] 3.99682 Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Source:Uniprot/SWISSPROT;Acc:Q9P232] 4.90535 DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Source:Uniprot/SWISSPROT;Acc:Q15038] 5.23046 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Source:Uniprot/SWISSPROT;Acc:P48736] 5.32612 Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Source:Uniprot/SWISSPROT;Acc:Q12968] 5.61927 RING finger protein 170 (Putative LAG1-interacting protein). [Source:Uniprot/SWISSPROT;Acc:Q96K19] 5.84607 Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Source:Uniprot/SWISSPROT;Acc:Q15813] 6.3909 Protein Jade-1 (PHD finger protein 17). [Source:Uniprot/SWISSPROT;Acc:Q6IE81] 6.56408 DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (DNA-directed RNA polymerase III subunit 22.9 kDa polypeptide). [Source:Uniprot/SWISSPROT;Acc:Q9Y535] Legend: - The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration. - The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. - The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. - The Gene Ontology terms as linked to the specific gene.

- http://analysis.yellowcouch.org/