MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
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description	Regulation	Ratio	Gene Ontology	Class	Gene	Accession	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 2019 to 2068 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	down	1.65835	translational elongation	biological process
			tRNA binding	molecular function
Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	up	1.21657	cell cycle	biological process
			cytokinesis
			GTP binding	molecular function
			GTPase activity
			nucleotide binding
			plasma membrane	cellular component
			positive regulation of exocytosis	biological process
			protein binding	molecular function
			regulation of exocytosis	biological process
			small GTPase mediated signal transduction
			structural molecule activity	molecular function
			synaptic vesicle	cellular component
			synaptic vesicle targeting	biological process
			synaptosome	cellular component
			syntaxin binding	molecular function
Serine/threonine-protein kinase Nek10 (EC 2.7.11.1) (NimA-related protein kinase 10). [Uniprot/SWISSPROT;Acc:Q6ZWH5]		6.50865	ATP binding
			magnesium ion binding
			nucleotide binding
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]		1.22178	ATP binding
			cytoplasm	cellular component
			cytosol
			heme binding	molecular function
			nucleotide binding
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein binding	molecular function
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
			transition metal ion binding
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	down	4.14557	ATP binding
			nucleotide binding
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			transferase activity
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]		2.31699	cytoplasm	cellular component
			hydrolase activity	molecular function
			iron ion binding
			manganese ion binding
			metal ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.