Scientific
MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis
These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.
Affected Genes

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Ratio Regulation Gene Ontology description Accession Class Gene Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX
Showing element 1051 to 1100 of 2667 in total
Ratio	Regulation	Gene Ontology	description	Class	
1.43351	down	metallopeptidase activity	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Source:Uniprot/SWISSPROT;Acc:P48052]	molecular function	
1.43351	down	proteolysis	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Source:Uniprot/SWISSPROT;Acc:P48052]	biological process	
1.43351	down	vacuolar protein catabolic process	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Source:Uniprot/SWISSPROT;Acc:P48052]	biological process	
1.43351	down	zinc ion binding	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Source:Uniprot/SWISSPROT;Acc:P48052]	molecular function	
1.44004	down	extracellular space	Cytokine-like protein 1 precursor (Protein C17). [Source:Uniprot/SWISSPROT;Acc:Q9NRR1]	cellular component	
1.44004	down	receptor binding	Cytokine-like protein 1 precursor (Protein C17). [Source:Uniprot/SWISSPROT;Acc:Q9NRR1]	molecular function	
1.44004	down	signal transduction	Cytokine-like protein 1 precursor (Protein C17). [Source:Uniprot/SWISSPROT;Acc:Q9NRR1]	biological process	
1.44004	down	soluble fraction	Cytokine-like protein 1 precursor (Protein C17). [Source:Uniprot/SWISSPROT;Acc:Q9NRR1]	cellular component	
1.44789	up	DNA binding	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	molecular function	
1.44789	up	humoral immune response	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	biological process	
1.44789	up	nucleus	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	cellular component	
1.44789	up	protein binding	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	molecular function	
1.44789	up	regulation of transcription, DNA-dependent	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	biological process	
1.44789	up	transcription	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	biological process	
1.44789	up	transcription coactivator activity	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	molecular function	
1.44789	up	transcription from RNA polymerase II promoter	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Source:Uniprot/SWISSPROT;Acc:Q16633]	biological process	
1.45148	up	DNA binding	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	molecular function	
1.45148	up	ER-Golgi intermediate compartment	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	Golgi apparatus	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	Golgi membrane	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	Golgi organization and biogenesis	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	biological process	
1.45148	up	Golgi stack	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	integral to membrane	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	membrane	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	nucleus	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	cellular component	
1.45148	up	protein binding	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	molecular function	
1.45148	up	regulation of transcription, DNA-dependent	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	biological process	
1.45148	up	vesicle-mediated transport	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Source:Uniprot/SWISSPROT;Acc:Q14789]	biological process	
1.45314	up	DNA binding	NULL	molecular function	
1.45624	up	circulation	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	DNA binding	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	molecular function	
1.45624	up	hemostasis	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	multicellular organismal development	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	nucleus	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	cellular component	
1.45624	up	protein dimerization activity	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	molecular function	
1.45624	up	regulation of transcription	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	regulation of transcription from RNA polymerase II promoter	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	regulation of transcription, DNA-dependent	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	biological process	
1.45624	up	sequence-specific DNA binding	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	molecular function	
1.45624	up	transcription coactivator activity	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	molecular function	
1.45624	up	transcription factor activity	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Source:Uniprot/SWISSPROT;Acc:Q16621]	molecular function	
1.45635	up	cell cycle	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	biological process	
1.45635	up	cell division	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	biological process	
1.45635	up	cytoplasm	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	cellular component	
1.45635	up	female pronucleus	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	cellular component	
1.45635	up	male pronucleus	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	cellular component	
1.45635	up	mitosis	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	biological process	
1.45635	up	mitotic G2 checkpoint	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	biological process	
1.45635	up	nucleus	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	cellular component	
1.45635	up	positive regulation of transcription	Cyclin-A2 (Cyclin-A). [Source:Uniprot/SWISSPROT;Acc:P20248]	biological process	

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells. 
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component. 
- The Gene Ontology terms as linked to the specific gene.
- http://analysis.yellowcouch.org/