MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Accession	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.43351	down	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]	metallopeptidase activity	molecular function
			proteolysis	biological process
			vacuolar protein catabolic process
			zinc ion binding	molecular function
1.44004		Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]	extracellular space	cellular component
			receptor binding	molecular function
			signal transduction	biological process
			soluble fraction	cellular component
1.44789	up	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]	DNA binding	molecular function
			humoral immune response	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription coactivator activity	molecular function
			transcription from RNA polymerase II promoter	biological process
1.45148		Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]	DNA binding	molecular function
			ER-Golgi intermediate compartment	cellular component
			Golgi apparatus
			Golgi membrane
			Golgi organization and biogenesis	biological process
			Golgi stack	cellular component
			integral to membrane
			membrane
			nucleus
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			vesicle-mediated transport
1.45314		NULL	DNA binding	molecular function
1.45624		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]	circulation	biological process
			DNA binding	molecular function
			hemostasis	biological process
			multicellular organismal development
			nucleus	cellular component
			protein dimerization activity	molecular function
			regulation of transcription	biological process
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			sequence-specific DNA binding	molecular function
			transcription coactivator activity
			transcription factor activity
1.45635		Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]	cell cycle	biological process
			cell division
			cytoplasm	cellular component
			female pronucleus
			male pronucleus
			mitosis	biological process
			mitotic G2 checkpoint
			nucleus	cellular component
			positive regulation of transcription	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.