MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Class	Gene Ontology	Gene	description	Accession	Minimum Ratio	Maximum Ratio

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Showing element 1 to 50 of 2667 in total

Regulation  : down

Ratio	Class	Gene Ontology	description
1.08658	molecular function	protein binding	pyrin and HIN domain family, member 1 alpha 1 isoform [RefSeq_peptide;Acc:NP_689714]
1.11083	biological process	neurotransmitter transport	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]
	cellular component	integral to plasma membrane
		membrane
		plasma membrane
	molecular function	neurotransmitter:sodium symporter activity
		symporter activity
		transporter activity
1.11956	biological process	retrograde vesicle-mediated transport, Golgi to ER	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]
	cellular component	Golgi apparatus
		integral to Golgi membrane
		integral to membrane
		membrane
	molecular function	molecular_function
1.1243	biological process	regulation of transcription, DNA-dependent	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]
		transcription
	cellular component	intracellular
		nucleus
	molecular function	DNA binding
		metal ion binding
		nucleic acid binding
		zinc ion binding
1.13541	biological process	blood coagulation	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]
		cell adhesion
		regulation of growth
	cellular component	extracellular region
		membrane
	molecular function	calcium ion binding
		protein binding
		structural molecule activity
		transmembrane receptor activity
1.14311	biological process	negative regulation of protein kinase activity	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]
		protein targeting
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
	cellular component	cytoplasm
	molecular function	insulin-like growth factor receptor binding
		protein domain specific binding
		protein kinase C binding
		protein kinase C inhibitor activity
1.1611	biological process	electron transport	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]
		signal transduction
	cellular component	extracellular region
	molecular function	electron carrier activity
		enzyme activator activity
		guanylate cyclase activator activity
		hormone activity
1.17859	cellular component	integral to membrane	XK-related protein 5. [Uniprot/SWISSPROT;Acc:Q6UX68]
		membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.